diff --git a/pkgs/development/python-modules/setproctitle/default.nix b/pkgs/development/python-modules/setproctitle/default.nix
index fdb412cb499e..e99a26990139 100644
--- a/pkgs/development/python-modules/setproctitle/default.nix
+++ b/pkgs/development/python-modules/setproctitle/default.nix
@@ -5,6 +5,7 @@
   setuptools,
   pytestCheckHook,
   procps,
+  stdenv,
 }:
 
 buildPythonPackage rec {
@@ -26,6 +27,9 @@ buildPythonPackage rec {
     procps
   ];
 
+  # Setting the process title fails on macOS in the Nix builder environment (regardless of sandboxing)
+  disabledTests = if stdenv.hostPlatform.isDarwin then [ "test_setproctitle_darwin" ] else null;
+
   pythonImportsCheck = [ "setproctitle" ];
 
   meta = {