diff --git a/pkgs/development/compilers/ocaml/generic.nix b/pkgs/development/compilers/ocaml/generic.nix
index b2a1896622c1..cfca2e9393a5 100644
--- a/pkgs/development/compilers/ocaml/generic.nix
+++ b/pkgs/development/compilers/ocaml/generic.nix
@@ -92,6 +92,11 @@ stdenv.mkDerivation (
 
     patches = map fetchpatch' patches;
 
+    # https://github.com/ocaml/ocaml/issues/14543
+    postPatch = if stdenv.cc.isClang then ''
+      rm testsuite/tests/basic/trigraph.ml
+    '' else null;
+
     strictDeps = true;
 
     prefixKey = "-prefix ";