diff --git a/pkgs/development/python-modules/anyqt/default.nix b/pkgs/development/python-modules/anyqt/default.nix
new file mode 100644
index 000000000000..a4fbb041822a
--- /dev/null
+++ b/pkgs/development/python-modules/anyqt/default.nix
@@ -0,0 +1,44 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, pyqt5
+, pytestCheckHook
+, nix-update-script
+}:
+
+buildPythonPackage rec {
+  pname = "anyqt";
+  version = "0.2.0";
+
+  src = fetchFromGitHub {
+    owner = "ales-erjavec";
+    repo = "anyqt";
+    rev = version;
+    hash = "sha256-dL2EUAMzWKq/oN3rXiEC6emDJddmg4KclT5ONKA0jfk=";
+  };
+
+  nativeCheckInputs = [ pyqt5 pytestCheckHook ];
+
+  # All of these fail because Qt modules cannot be imported
+  disabledTestPaths = [
+    "tests/test_qabstractitemview.py"
+    "tests/test_qaction_set_menu.py"
+    "tests/test_qactionevent_action.py"
+    "tests/test_qfontdatabase_static.py"
+    "tests/test_qpainter_draw_pixmap_fragments.py"
+    "tests/test_qsettings.py"
+    "tests/test_qstandarditem_insertrow.py"
+    "tests/test_qtest.py"
+  ];
+
+  pythonImportsCheck = [ "AnyQt" ];
+
+  passthru.updateScript = nix-update-script { };
+
+  meta = {
+    description = "PyQt/PySide compatibility layer";
+    homepage = "https://github.com/ales-erjavec/anyqt";
+    license = [ lib.licenses.gpl3Only ];
+    maintainers = [ lib.maintainers.lucasew ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 179c42864420..984ed5d3a47e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -552,6 +552,8 @@ self: super: with self; {
 
   anyio = callPackage ../development/python-modules/anyio { };
 
+  anyqt = callPackage ../development/python-modules/anyqt { };
+
   anytree = callPackage ../development/python-modules/anytree {
     inherit (pkgs) graphviz;
   };