diff --git a/pkgs/development/python-modules/ledger-agent/default.nix b/pkgs/development/python-modules/ledger-agent/default.nix
deleted file mode 100644
index 12a16dc0ecad..000000000000
--- a/pkgs/development/python-modules/ledger-agent/default.nix
+++ /dev/null
@@ -1,43 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchPypi,
-  ledgerblue,
-  setuptools,
-  libagent,
-  wheel,
-}:
-
-buildPythonPackage rec {
-  pname = "ledger-agent";
-  version = "0.9.0";
-  format = "setuptools";
-
-  src = fetchPypi {
-    pname = "ledger_agent";
-    inherit version;
-    sha256 = "03zj602m2rln9yvr08dswy56vzkbldp8b074ixwzz525dafblr92";
-  };
-
-  propagatedBuildInputs = [
-    ledgerblue
-    libagent
-    setuptools
-    wheel
-  ];
-
-  # no tests
-  doCheck = false;
-
-  meta = {
-    description = "Using Ledger as hardware-based SSH/PGP agent";
-    homepage = "https://github.com/romanz/trezor-agent";
-    license = lib.licenses.gpl3;
-    maintainers = with lib.maintainers; [
-      hkjn
-      np
-      mmahut
-    ];
-    platforms = lib.platforms.linux;
-  };
-}
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index f90d3bc228a6..580b4bebd7ba 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1096,7 +1096,8 @@ mapAliases {
   layan-kde = throw "'layan-kde' has been removed, as it is only compatible with Plasma 5, which is EOL"; # Added 2025-08-20
   lazarus-qt = throw "'lazarus-qt' has been renamed to/replaced by 'lazarus-qt5'"; # Converted to throw 2025-10-27
   leaf = throw "'leaf' has been removed as it is unmaintained. Consider using 'fastfetch' instead"; # Added 2026-04-24
-  ledger_agent = throw "'ledger_agent' has been renamed to/replaced by 'ledger-agent'"; # Converted to throw 2025-10-27
+  ledger-agent = throw "ledger-agent has been removed because upstream dropped Ledger support"; # Added 2026-03-11
+  ledger_agent = throw "ledger-agent has been removed because upstream dropped Ledger support"; # Added 2026-03-11
   lesstif = throw "'lesstif' has been removed due to its being broken and unmaintained upstream. Consider using 'motif' instead."; # Added 2025-06-09
   lexical = throw "'lexical' has been removed because it was deprecated and archived upstream. Consider using 'beamPackages.expert' instead"; # Added 2026-02-24
   lfs = throw "'lfs' has been renamed to/replaced by 'dysk'"; # Converted to throw 2025-10-27
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 2e03b9f6bd42..b9619a0ad816 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -10427,8 +10427,6 @@ with pkgs;
     withGui = false;
   };
 
-  ledger-agent = with python3Packages; toPythonApplication ledger-agent;
-
   napari = with python312Packages; toPythonApplication napari;
 
   pycoin = with python3Packages; toPythonApplication pycoin;
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index cab9f0304b63..7350b189341f 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -306,7 +306,8 @@ mapAliases {
   lazy_imports = throw "'lazy_imports' has been renamed to/replaced by 'lazy-imports'"; # Converted to throw 2025-10-29
   lcov_cobertura = throw "'lcov_cobertura' has been renamed to/replaced by 'lcov-cobertura'"; # Converted to throw 2025-10-29
   ldap = throw "'ldap' has been renamed to/replaced by 'python-ldap'"; # Converted to throw 2025-10-29
-  ledger_agent = throw "'ledger_agent' has been renamed to/replaced by 'ledger-agent'"; # Converted to throw 2025-10-29
+  ledger-agent = throw "ledger-agent has been removed because upstream dropped Ledger support"; # Added 2026-03-11
+  ledger_agent = throw "ledger-agent has been removed because upstream dropped Ledger support"; # Added 2026-03-11
   libarcus = throw "'libarcus' has been removed, as it was unmaintained in nixpkgs"; # Added 2026-05-22
   libgpiod = gpiod; # added 2026-03-30
   libpyfoscam = throw "libpyfoscam was removed because Home Assistant switched to libpyfoscamcgi"; # added 2025-07-03
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 9ec209a65225..207f461fcd1f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8726,8 +8726,6 @@ self: super: with self; {
       }
     )).py;
 
-  ledger-agent = callPackage ../development/python-modules/ledger-agent { };
-
   ledger-bitcoin = callPackage ../development/python-modules/ledger-bitcoin { };
 
   ledgerblue = callPackage ../development/python-modules/ledgerblue { };