diff --git a/pkgs/development/python-modules/llm/default.nix b/pkgs/development/python-modules/llm/default.nix
index 7b8098c86227..a943c405d447 100644
--- a/pkgs/development/python-modules/llm/default.nix
+++ b/pkgs/development/python-modules/llm/default.nix
@@ -228,6 +228,17 @@ let
       "tests/"
     ];
 
+    disabledTests = [
+      # AssertionError: The following responses are mocked but not requested:
+      # - Match POST request on https://api.openai.com/v1/chat/completions
+      # https://github.com/simonw/llm/issues/1292
+      "test_gpt4o_mini_sync_and_async"
+
+      # TypeError: CliRunner.__init__() got an unexpected keyword argument 'mix_stderr
+      # https://github.com/simonw/llm/issues/1293
+      "test_embed_multi_files_encoding"
+    ];
+
     pythonImportsCheck = [ "llm" ];
 
     passthru = {
diff --git a/pkgs/development/python-modules/symbex/default.nix b/pkgs/development/python-modules/symbex/default.nix
index 47405f4b8223..94cb8baf6d0b 100644
--- a/pkgs/development/python-modules/symbex/default.nix
+++ b/pkgs/development/python-modules/symbex/default.nix
@@ -35,6 +35,15 @@ buildPythonPackage rec {
     writableTmpDirAsHomeHook
   ];
 
+  disabledTests = [
+    # Broken due to click 8.2.0 update
+    # https://github.com/simonw/symbex/issues/48
+    "test_output"
+    "test_replace"
+    "test_replace_errors"
+    "test_errors"
+  ];
+
   meta = {
     description = "Find the Python code for specified symbols";
     homepage = "https://github.com/simonw/symbex";