diff --git a/pkgs/by-name/ht/htslib/package.nix b/pkgs/by-name/ht/htslib/package.nix
index f38569688570..a750883ac0ec 100644
--- a/pkgs/by-name/ht/htslib/package.nix
+++ b/pkgs/by-name/ht/htslib/package.nix
@@ -2,6 +2,7 @@
   lib,
   stdenv,
   fetchurl,
+  fetchpatch,
   zlib,
   bzip2,
   xz,
@@ -11,13 +12,20 @@
 
 stdenv.mkDerivation rec {
   pname = "htslib";
-  version = "1.21";
+  version = "1.22";
 
   src = fetchurl {
     url = "https://github.com/samtools/htslib/releases/download/${version}/${pname}-${version}.tar.bz2";
-    sha256 = "sha256-hLUQ5zX0ljZB8m/YjIq97oH/TLYhaDEK5xZjaqwPGCM=";
+    hash = "sha256-YlDB3yl9tHdRbmCsjfRe11plLR8lsPN/EvWxcmnq/ek=";
   };
 
+  patches = [
+    (fetchpatch {
+      url = "https://github.com/samtools/htslib/commit/31006e1c8edd02eb6321ed9be76b84fca5d20cb6.patch";
+      hash = "sha256-sbnkVmXIbs/Cn/msUUrJpJZCI2DHX5kpGSka2cccZIQ=";
+    })
+  ];
+
   # perl is only used during the check phase.
   nativeBuildInputs = [ perl ];