diff --git a/pkgs/data/themes/cdetheme/default.nix b/pkgs/data/themes/cdetheme/default.nix
deleted file mode 100644
index a2d6568b9a87..000000000000
--- a/pkgs/data/themes/cdetheme/default.nix
+++ /dev/null
@@ -1,34 +0,0 @@
-{ lib, stdenv, fetchFromGitHub, python2Packages }:
-
-stdenv.mkDerivation rec {
-  pname = "cdetheme";
-  version = "1.3";
-
-  src = fetchFromGitHub {
-    owner = "josvanr";
-    repo = "cde-motif-theme";
-    rev = version;
-    sha256 = "1v5c4db69cmzdci8xxlkx3s3cifg1h5160qq5siwfps0sj7pvggj";
-  };
-
-  dontBuild = true;
-
-  pythonPath = with python2Packages; [ pyqt4 pillow pyxdg pyyaml ];
-  nativeBuildInputs = with python2Packages; [ python wrapPython ];
-
-  installPhase = ''
-    mkdir -p $out/share/themes
-    cp -r cdetheme $out/share/themes
-    patchShebangs $out/share/themes/cdetheme/scripts/switchtheme
-    wrapPythonProgramsIn "$out/share/themes/cdetheme/scripts" "$out $pythonPath"
-  '';
-
-  meta = with lib; {
-    description = "Gtk2 / Gtk3 theme mimicking CDE / Motif";
-    homepage = "https://www.gnome-look.org/p/1231025";
-    license = licenses.gpl3;
-    platforms = platforms.all;
-    maintainers = with maintainers; [ ];
-    hydraPlatforms = [];
-  };
-}
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 989901ccb078..cb8c5e0e1ca2 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -118,6 +118,7 @@ mapAliases ({
   casperjs = throw "casperjs has been removed, it was abandoned by upstream and broken.";
   catfish = xfce.catfish; # added 2019-12-22
   ccnet = throw "ccnet has been removed because seafile does not depend on it anymore"; # added 2021-03-25
+  cde-gtk-theme = throw "cde-gtk-theme has been removed from nixpkgs as it shipped with python2 scripts that didn't work anymore."; # added 2022-01-12
   cgmanager = throw "cgmanager was deprecated by lxc and therefore removed from nixpkgs."; # added 2020-06-05
   checkbashism = checkbashisms; # added 2016-08-16
   chronos = throw "chronos has been removed from nixpkgs, as it was unmaintained"; # added 2020-08-15
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index e5bed7458972..39678ca427a9 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -23281,8 +23281,6 @@ with pkgs;
 
   cascadia-code = callPackage ../data/fonts/cascadia-code { };
 
-  cde-gtk-theme = callPackage ../data/themes/cdetheme { };
-
   charis-sil = callPackage ../data/fonts/charis-sil { };
 
   cherry = callPackage ../data/fonts/cherry { inherit (xorg) fonttosfnt mkfontdir; };