diff --git a/pkgs/development/compilers/mlton/20130715.nix b/pkgs/development/compilers/mlton/20130715.nix
index ed460b7e5cfe..766111dc012a 100644
--- a/pkgs/development/compilers/mlton/20130715.nix
+++ b/pkgs/development/compilers/mlton/20130715.nix
@@ -29,11 +29,6 @@ stdenv.mkDerivation rec {
         url = "mirror://sourceforge/project/mlton/mlton/${version}/${pname}-${version}-1.amd64-linux.tgz";
         hash = "sha256-9vkSAJsJRrc6+I/18+cTtr5juHFpbiaXzPFWS1bn0Ds=";
       })
-    else if stdenv.hostPlatform.system == "x86_64-darwin" then
-      (fetchurl {
-        url = "mirror://sourceforge/project/mlton/mlton/${version}/${pname}-${version}-1.amd64-darwin.gmp-macports.tgz";
-        hash = "sha256-qb//O8Wnk+hDBvmM1g8ZWoE5kCkA+W4QctE8CBO0nBA=";
-      })
     else
       throw "Architecture not supported";
 
@@ -76,9 +71,6 @@ stdenv.mkDerivation rec {
   ''
   + lib.optionalString stdenv.cc.isClang ''
     sed -i "s_	patch -s -p0 <gdtoa.hide-public-fns.patch_	patch -s -p0 <gdtoa.hide-public-fns.patch\n\tsed -i 's|printf(emptyfmt|printf(\"\"|g' ./gdtoa/arithchk.c_" ./runtime/Makefile
-  ''
-  + lib.optionalString stdenv.hostPlatform.isDarwin ''
-    sed -i 's|XCFLAGS += -I/usr/local/include -I/sw/include -I/opt/local/include||' ./runtime/Makefile
   '';
 
   preBuild = ''
@@ -93,19 +85,11 @@ stdenv.mkDerivation rec {
     # So the builder runs the binary compiler with gmp.
     export LD_LIBRARY_PATH=${gmp.out}/lib''${LD_LIBRARY_PATH:+:}$LD_LIBRARY_PATH
 
-  ''
-  + lib.optionalString stdenv.hostPlatform.isLinux ''
     # Patch ELF interpreter.
     patchelf --set-interpreter ${dynamic_linker} $(pwd)/../${usr_prefix}/lib/mlton/mlton-compile
     for e in mllex mlyacc ; do
       patchelf --set-interpreter ${dynamic_linker} $(pwd)/../${usr_prefix}/bin/$e
     done
-  ''
-  + lib.optionalString stdenv.hostPlatform.isDarwin ''
-    # Patch libgmp linking
-    install_name_tool -change /opt/local/lib/libgmp.10.dylib ${gmp}/lib/libgmp.10.dylib $(pwd)/../${usr_prefix}/lib/mlton/mlton-compile
-    install_name_tool -change /opt/local/lib/libgmp.10.dylib ${gmp}/lib/libgmp.10.dylib $(pwd)/../${usr_prefix}/bin/mlyacc
-    install_name_tool -change /opt/local/lib/libgmp.10.dylib ${gmp}/lib/libgmp.10.dylib $(pwd)/../${usr_prefix}/bin/mllex
   '';
 
   doCheck = true;
diff --git a/pkgs/development/compilers/mlton/20180207-binary.nix b/pkgs/development/compilers/mlton/20180207-binary.nix
index 324abd0a16e9..773e8f3d322b 100644
--- a/pkgs/development/compilers/mlton/20180207-binary.nix
+++ b/pkgs/development/compilers/mlton/20180207-binary.nix
@@ -18,11 +18,6 @@ stdenv.mkDerivation rec {
         url = "https://github.com/MLton/mlton/releases/download/on-${version}-release/${pname}-${version}-1.amd64-linux.tgz";
         hash = "sha256-jkq9ufPvgcAbmJpmc03KKn9BicVWc6HIu61U58spmDg=";
       })
-    else if stdenv.hostPlatform.system == "x86_64-darwin" then
-      (fetchurl {
-        url = "https://github.com/MLton/mlton/releases/download/on-${version}-release/${pname}-${version}-1.amd64-darwin.gmp-static.tgz";
-        hash = "sha256-uy2YLvl9bvTv4HjSOgm68+Uvb9bI8aYAFuFiRDj0h7M=";
-      })
     else
       throw "Architecture not supported";
 
@@ -40,29 +35,15 @@ stdenv.mkDerivation rec {
     make install PREFIX=$out
   '';
 
-  postFixup =
-    lib.optionalString stdenv.hostPlatform.isLinux ''
-      patchelf --set-interpreter ${dynamic-linker} $out/lib/mlton/mlton-compile
-      patchelf --set-rpath ${gmp}/lib $out/lib/mlton/mlton-compile
+  postFixup = ''
+    patchelf --set-interpreter ${dynamic-linker} $out/lib/mlton/mlton-compile
+    patchelf --set-rpath ${gmp}/lib $out/lib/mlton/mlton-compile
 
-      for e in mllex mlnlffigen mlprof mlyacc; do
-        patchelf --set-interpreter ${dynamic-linker} $out/bin/$e
-        patchelf --set-rpath ${gmp}/lib $out/bin/$e
-      done
-    ''
-    + lib.optionalString stdenv.hostPlatform.isDarwin ''
-      install_name_tool -change \
-        /opt/local/lib/libgmp.10.dylib \
-        ${gmp}/lib/libgmp.10.dylib \
-        $out/lib/mlton/mlton-compile
-
-      for e in mllex mlnlffigen mlprof mlyacc; do
-        install_name_tool -change \
-          /opt/local/lib/libgmp.10.dylib \
-          ${gmp}/lib/libgmp.10.dylib \
-          $out/bin/$e
-      done
-    '';
+    for e in mllex mlnlffigen mlprof mlyacc; do
+      patchelf --set-interpreter ${dynamic-linker} $out/bin/$e
+      patchelf --set-rpath ${gmp}/lib $out/bin/$e
+    done
+  '';
 
   meta = import ./meta.nix { inherit lib; };
 }
diff --git a/pkgs/development/compilers/mlton/20210117-binary.nix b/pkgs/development/compilers/mlton/20210117-binary.nix
index 94c79d70d3cf..625a8bddb8b5 100644
--- a/pkgs/development/compilers/mlton/20210117-binary.nix
+++ b/pkgs/development/compilers/mlton/20210117-binary.nix
@@ -20,11 +20,6 @@ stdenv.mkDerivation rec {
         url = "https://github.com/MLton/mlton/releases/download/on-${version}-release/${pname}-${version}-1.amd64-linux-glibc2.31.tgz";
         hash = "sha256-dJy1nWuszWRBQ3Cb6GYQUijSttzUDFB6kLicm14PRdI=";
       })
-    else if stdenv.hostPlatform.system == "x86_64-darwin" then
-      (fetchurl {
-        url = "https://github.com/MLton/mlton/releases/download/on-${version}-release/${pname}-${version}-1.amd64-darwin-19.6.gmp-static.tgz";
-        hash = "sha256-W+qfYBNupoR4kMX05F1xJqMu8U/UaiMDyrh1ypXIzXY=";
-      })
     else if stdenv.hostPlatform.system == "aarch64-darwin" then
       (fetchurl {
         url = "https://projects.laas.fr/tina/software/mlton-${version}-1.arm64-darwin-21.6-gmp-static.tgz";
diff --git a/pkgs/development/compilers/mlton/20241230-binary.nix b/pkgs/development/compilers/mlton/20241230-binary.nix
index dbc7cdb05bc4..25e1b8aa6a7b 100644
--- a/pkgs/development/compilers/mlton/20241230-binary.nix
+++ b/pkgs/development/compilers/mlton/20241230-binary.nix
@@ -24,11 +24,6 @@ stdenv.mkDerivation rec {
         url = "https://github.com/MLton/mlton/releases/download/on-${version}-release/${pname}-${version}-1.arm64-linux.ubuntu-24.04-arm_glibc2.39.tgz";
         hash = "sha256-rn65t253SfUShAM3kXiLQJHT7JS7EO3fAPB23LWIwfc=";
       })
-    else if stdenv.hostPlatform.system == "x86_64-darwin" then
-      (fetchurl {
-        url = "https://github.com/MLton/mlton/releases/download/on-${version}-release/${pname}-${version}-1.amd64-darwin.macos-13_gmp-static.tgz";
-        hash = "sha256-fW0hqjrWUcy+PIN8WHb1r4EYgfuwF9Zz3q7f2ZtxOi0=";
-      })
     else if stdenv.hostPlatform.system == "aarch64-darwin" then
       (fetchurl {
         url = "https://github.com/MLton/mlton/releases/download/on-${version}-release/${pname}-${version}-1.arm64-darwin.macos-15_gmp-static.tgz";
diff --git a/pkgs/development/compilers/mlton/default.nix b/pkgs/development/compilers/mlton/default.nix
index c51e41d14f59..89e4ee50a531 100644
--- a/pkgs/development/compilers/mlton/default.nix
+++ b/pkgs/development/compilers/mlton/default.nix
@@ -29,7 +29,7 @@ rec {
     rev = "on-20241230-release";
     hash = "sha256-gJUzav2xH8C4Vy5FuqN73Z6lPMSPQgJApF8LgsJXRWo=";
     # https://github.com/MLton/mlton/issues/631
-    doCheck = !(stdenv.hostPlatform.isAarch64 && stdenv.hostPlatform.isDarwin);
+    doCheck = !stdenv.hostPlatform.isDarwin;
   };
 
   mltonHEAD = callPackage ./from-git-source.nix {
@@ -38,6 +38,6 @@ rec {
     rev = "61baac7108fbd91413f0537b7a42d9a1023455f4";
     hash = "sha256-nWR7ZaXfKxeXfZ9IHipAQ39ASVtva4BeDHP3Zq8mqPo=";
     # https://github.com/MLton/mlton/issues/631
-    doCheck = !(stdenv.hostPlatform.isAarch64 && stdenv.hostPlatform.isDarwin);
+    doCheck = !stdenv.hostPlatform.isDarwin;
   };
 }