diff --git a/pkgs/development/python-modules/quart-trio/default.nix b/pkgs/development/python-modules/quart-trio/default.nix
new file mode 100644
index 000000000000..67170265ca70
--- /dev/null
+++ b/pkgs/development/python-modules/quart-trio/default.nix
@@ -0,0 +1,65 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  pythonOlder,
+
+  # build-system
+  pdm-backend,
+
+  # dependencies
+  exceptiongroup,
+  hypercorn,
+  quart,
+  trio,
+
+  # tests
+  pytest-cov-stub,
+  pytest-trio,
+  pytestCheckHook,
+}:
+
+buildPythonPackage rec {
+  pname = "quart-trio";
+  version = "0.12.0";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "pgjones";
+    repo = "quart-trio";
+    tag = version;
+    hash = "sha256-n41XATex20iw3ZYxud/5cTdx+F6tTQQJmP91TIw2xJo=";
+  };
+
+  build-system = [
+    pdm-backend
+  ];
+
+  dependencies = [
+    hypercorn
+    quart
+    trio
+  ]
+  ++ hypercorn.optional-dependencies.trio
+  ++ lib.optionals (pythonOlder "3.11") [
+    exceptiongroup
+  ];
+
+  pythonImportsCheck = [
+    "quart_trio"
+  ];
+
+  nativeCheckInputs = [
+    pytest-cov-stub
+    pytest-trio
+    pytestCheckHook
+  ];
+
+  meta = {
+    description = "Quart-Trio is an extension for Quart to support the Trio event loop";
+    homepage = "https://github.com/pgjones/quart-trio";
+    changelog = "https://github.com/pgjones/quart-trio/blob/${src.tag}/CHANGELOG.rst";
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ hexa ];
+  };
+}
diff --git a/pkgs/development/python-modules/urllib3/default.nix b/pkgs/development/python-modules/urllib3/default.nix
index b8404d98e988..30ab03edc694 100644
--- a/pkgs/development/python-modules/urllib3/default.nix
+++ b/pkgs/development/python-modules/urllib3/default.nix
@@ -9,27 +9,34 @@
   hatch-vcs,
 
   # optional-dependencies
+  backports-zstd,
   brotli,
   brotlicffi,
+  h2,
   pysocks,
-  zstandard,
 
   # tests
+  httpx,
+  pyopenssl,
   pytestCheckHook,
+  pytest-socket,
   pytest-timeout,
+  quart,
+  quart-trio,
   tornado,
+  trio,
   trustme,
 }:
 
 let
   self = buildPythonPackage rec {
     pname = "urllib3";
-    version = "2.5.0";
+    version = "2.6.0";
     pyproject = true;
 
     src = fetchPypi {
       inherit pname version;
-      hash = "sha256-P8R3M8fkGdS8P2s9wrT4kLt0OQajDVa6Slv6S7/5J2A=";
+      hash = "sha256-y5vO9aSzRdXaXRRdw+MINPWOgBiCjLxyTTC0y31NSfE=";
     };
 
     build-system = [
@@ -39,23 +46,34 @@ let
 
     postPatch = ''
       substituteInPlace pyproject.toml \
-        --replace-fail ', "setuptools-scm>=8,<9"' ""
+        --replace-fail ', "setuptools-scm>=8,<10"' ""
     '';
 
     optional-dependencies = {
       brotli = if isPyPy then [ brotlicffi ] else [ brotli ];
+      h2 = [ h2 ];
       socks = [ pysocks ];
-      zstd = [ zstandard ];
+      zstd = [ backports-zstd ];
     };
 
     nativeCheckInputs = [
+      httpx
+      pyopenssl
+      pytest-socket
       pytest-timeout
       pytestCheckHook
+      quart
+      quart-trio
       tornado
+      trio
       trustme
     ]
     ++ lib.concatAttrValues optional-dependencies;
 
+    disabledTestMarks = [
+      "requires_network"
+    ];
+
     # Tests in urllib3 are mostly timeout-based instead of event-based and
     # are therefore inherently flaky. On your own machine, the tests will
     # typically build fine, but on a loaded cluster such as Hydra random
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f33f36ae7125..8b341b3ddeb0 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -15955,6 +15955,8 @@ self: super: with self; {
 
   quart-schema = callPackage ../development/python-modules/quart-schema { };
 
+  quart-trio = callPackage ../development/python-modules/quart-trio { };
+
   quaternion = callPackage ../development/python-modules/quaternion { };
 
   qudida = callPackage ../development/python-modules/qudida { };