diff --git a/pkgs/development/python-modules/greenlet/default.nix b/pkgs/development/python-modules/greenlet/default.nix
index aecb96244991..fdabde2bb65a 100644
--- a/pkgs/development/python-modules/greenlet/default.nix
+++ b/pkgs/development/python-modules/greenlet/default.nix
@@ -1,4 +1,5 @@
 {
+  stdenv,
   lib,
   buildPythonPackage,
   fetchPypi,
@@ -35,6 +36,9 @@ let
       unittestCheckHook
     ];
 
+    # https://github.com/python-greenlet/greenlet/issues/395
+    env.NIX_CFLAGS_COMPILE = lib.optionalString stdenv.hostPlatform.isPower64 "-fomit-frame-pointer";
+
     preCheck = ''
       pushd ${placeholder "out"}/${python.sitePackages}
     '';