diff --git a/pkgs/by-name/ct/ctranslate2/package.nix b/pkgs/by-name/ct/ctranslate2/package.nix
index aaa3cbb13e27..f97a6e1e4658 100644
--- a/pkgs/by-name/ct/ctranslate2/package.nix
+++ b/pkgs/by-name/ct/ctranslate2/package.nix
@@ -28,14 +28,14 @@ let
 in
 stdenv'.mkDerivation (finalAttrs: {
   pname = "ctranslate2";
-  version = "4.6.0";
+  version = "4.6.1";
 
   src = fetchFromGitHub {
     owner = "OpenNMT";
     repo = "CTranslate2";
     tag = "v${finalAttrs.version}";
     fetchSubmodules = true;
-    hash = "sha256-EM2kunqtxo0BTIzrEomfaRsdav7sx6QEOhjDtjjSoYY=";
+    hash = "sha256-nnbBK1dIHwhq8n1mJe2wOLcDkIuScFbQwZvJ8x+knCk=";
   };
 
   # Fix CMake 4 compatibility
diff --git a/pkgs/development/python-modules/ctranslate2/default.nix b/pkgs/development/python-modules/ctranslate2/default.nix
index 018490ff8dac..26de059fba7b 100644
--- a/pkgs/development/python-modules/ctranslate2/default.nix
+++ b/pkgs/development/python-modules/ctranslate2/default.nix
@@ -27,6 +27,11 @@ buildPythonPackage rec {
   # https://github.com/OpenNMT/CTranslate2/tree/master/python
   sourceRoot = "${src.name}/python";
 
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail "pybind11==" "pybind11>="
+  '';
+
   build-system = [
     pybind11
     setuptools