diff --git a/pkgs/by-name/mu/multiqc/package.nix b/pkgs/by-name/mu/multiqc/package.nix
index 71298537d3bf..320da0f89667 100644
--- a/pkgs/by-name/mu/multiqc/package.nix
+++ b/pkgs/by-name/mu/multiqc/package.nix
@@ -44,9 +44,8 @@ python3Packages.buildPythonApplication (finalAttrs: {
 
   sourceRoot = "multiqc";
 
-  nativeBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
     setuptools
-    wheel
   ];
 
   dependencies = with python3Packages; [
@@ -78,25 +77,6 @@ python3Packages.buildPythonApplication (finalAttrs: {
     jsonschema
   ];
 
-  optional-dependencies = {
-    dev = with python3Packages; [
-      pre-commit-hooks
-      pdoc3
-      pytest
-      pytest-cov
-      pytest-xdist
-      syrupy
-      pygithub
-      mypy
-      types-pyyaml
-      types-tqdm
-      types-requests
-      types-markdown
-      types-beautifulsoup4
-      types-pillow
-    ];
-  };
-
   # Some tests run subprocess.run() with "multiqc"
   preCheck = ''
     chmod -R u+w ../test-data