diff --git a/pkgs/development/libraries/pyotherside/default.nix b/pkgs/development/libraries/pyotherside/default.nix
index 481093cbe188..c9f1412b0457 100644
--- a/pkgs/development/libraries/pyotherside/default.nix
+++ b/pkgs/development/libraries/pyotherside/default.nix
@@ -5,11 +5,15 @@
   python3,
   qmake,
   qtbase,
-  qtquickcontrols,
+  qtdeclarative,
+  qtquickcontrols ? null, # Qt6: merged into qtdeclarative
   qtsvg,
   ncurses,
 }:
 
+let
+  withQt6 = lib.strings.versionAtLeast qtbase.version "6";
+in
 stdenv.mkDerivation rec {
   pname = "pyotherside";
   version = "1.6.2";
@@ -25,7 +29,7 @@ stdenv.mkDerivation rec {
   buildInputs = [
     python3
     qtbase
-    qtquickcontrols
+    (if withQt6 then qtdeclarative else qtquickcontrols)
     qtsvg
     ncurses
   ];
@@ -36,7 +40,7 @@ stdenv.mkDerivation rec {
   installTargets = [ "sub-src-install_subtargets" ];
 
   meta = {
-    description = "Asynchronous Python 3 Bindings for Qt 5";
+    description = "Asynchronous Python 3 Bindings for Qt ${lib.versions.major qtbase.version}";
     homepage = "https://thp.io/2011/pyotherside/";
     license = lib.licenses.isc;
     maintainers = [ lib.maintainers.mic92 ];
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index a093826a3754..7c03c05c46ae 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1738,7 +1738,7 @@ mapAliases {
   pyCA = warnAlias "'pyCA' was renamed to 'pyca'" pyca; # Added 2026-02-12
   pyload-ng = throw "'pyload-ng' has been removed due to vulnerabilities and being unmaintained"; # Added 2026-03-21
   pyo3-pack = throw "'pyo3-pack' has been renamed to/replaced by 'maturin'"; # Converted to throw 2025-10-27
-  pyotherside = warnAlias "'pyotherside' has been renamed to 'libsForQt5.pyotherside'."; # Added 2026-03-27
+  pyotherside = warnAlias "'pyotherside' has been renamed to 'libsForQt5.pyotherside'. A Qt6 build is available at 'qt6Packages.pyotherside'."; # Added 2026-03-27
   pypolicyd-spf = throw "'pypolicyd-spf' has been renamed to/replaced by 'spf-engine'"; # Converted to throw 2025-10-27
   python3Full = throw "python3Full has been removed. Bluetooth support is now enabled by default. The tkinter package is available within the package set."; # Added 2025-08-30
   python311Full = throw "python311Full has been removed. Bluetooth support is now enabled by default. The tkinter package is available within the package set."; # Added 2025-08-30
diff --git a/pkgs/top-level/qt6-packages.nix b/pkgs/top-level/qt6-packages.nix
index cc1b5fec45b7..d17adae73183 100644
--- a/pkgs/top-level/qt6-packages.nix
+++ b/pkgs/top-level/qt6-packages.nix
@@ -92,6 +92,8 @@ makeScopeWithSplicing' {
 
       maplibre-native-qt = callPackage ../development/libraries/maplibre-native-qt { };
 
+      pyotherside = callPackage ../development/libraries/pyotherside { };
+
       qca = callPackage ../development/libraries/qca {
         inherit (qt6) qtbase qt5compat;
       };