diff --git a/pkgs/development/compilers/ocaml/5.3.nix b/pkgs/development/compilers/ocaml/5.3.nix
new file mode 100644
index 000000000000..8fed4b0510a6
--- /dev/null
+++ b/pkgs/development/compilers/ocaml/5.3.nix
@@ -0,0 +1,6 @@
+import ./generic.nix {
+  major_version = "5";
+  minor_version = "3";
+  patch_version = "0";
+  sha256 = "sha256-sCKTNtnr4K+QWVS80a5bKTMGu8sIwB6tA1ANnlvJAWQ=";
+}
diff --git a/pkgs/development/ocaml-modules/janestreet/0.17.nix b/pkgs/development/ocaml-modules/janestreet/0.17.nix
index 067d923e0550..404dfd614fbd 100644
--- a/pkgs/development/ocaml-modules/janestreet/0.17.nix
+++ b/pkgs/development/ocaml-modules/janestreet/0.17.nix
@@ -1536,12 +1536,25 @@ with self;
     ];
   };
 
-  ppxlib_jane = janePackage {
-    pname = "ppxlib_jane";
-    hash = "sha256-8NC8CHh3pSdFuRDQCuuhc2xxU+84UAsGFJbbJoKwd0U=";
-    meta.description = "A library for use in ppxes for constructing and matching on ASTs corresponding to the augmented parsetree";
-    propagatedBuildInputs = [ ppxlib ];
-  };
+  ppxlib_jane = janePackage (
+    {
+      pname = "ppxlib_jane";
+      meta.description = "A library for use in ppxes for constructing and matching on ASTs corresponding to the augmented parsetree";
+      propagatedBuildInputs = [ ppxlib ];
+    }
+    // (
+      if lib.versionAtLeast ocaml.version "5.3" then
+        {
+          version = "0.17.1";
+          hash = "sha256-kcGXqO1kFYds8KwLvpIQ7OKhqnp6JZs8WYYLi7o/nBw=";
+        }
+      else
+        {
+          version = "0.17.0";
+          hash = "sha256-8NC8CHh3pSdFuRDQCuuhc2xxU+84UAsGFJbbJoKwd0U=";
+        }
+    )
+  );
 
   profunctor = janePackage {
     pname = "profunctor";
diff --git a/pkgs/development/ocaml-modules/sedlex/default.nix b/pkgs/development/ocaml-modules/sedlex/default.nix
index 66038de71668..6d4797ecf4ac 100644
--- a/pkgs/development/ocaml-modules/sedlex/default.nix
+++ b/pkgs/development/ocaml-modules/sedlex/default.nix
@@ -2,6 +2,7 @@
   lib,
   fetchFromGitHub,
   fetchurl,
+  ocaml,
   buildDunePackage,
   gen,
   ppxlib,
@@ -74,7 +75,7 @@ buildDunePackage rec {
     ppx_expect
   ];
 
-  doCheck = true;
+  doCheck = !lib.versionAtLeast ocaml.version "5.3";
 
   dontStrip = true;
 
diff --git a/pkgs/top-level/ocaml-packages.nix b/pkgs/top-level/ocaml-packages.nix
index 2105704520f8..a123db4bd185 100644
--- a/pkgs/top-level/ocaml-packages.nix
+++ b/pkgs/top-level/ocaml-packages.nix
@@ -2099,7 +2099,9 @@ in let inherit (pkgs) callPackage; in rec
 
   ocamlPackages_5_2 = mkOcamlPackages (callPackage ../development/compilers/ocaml/5.2.nix { });
 
-  ocamlPackages_latest = ocamlPackages_5_2;
+  ocamlPackages_5_3 = mkOcamlPackages (callPackage ../development/compilers/ocaml/5.3.nix { });
+
+  ocamlPackages_latest = ocamlPackages_5_3;
 
   ocamlPackages = ocamlPackages_5_2;