diff --git a/pkgs/development/python-modules/pyzstd/default.nix b/pkgs/development/python-modules/pyzstd/default.nix
new file mode 100644
index 000000000000..62e77d821d08
--- /dev/null
+++ b/pkgs/development/python-modules/pyzstd/default.nix
@@ -0,0 +1,62 @@
+{
+  buildPythonPackage,
+  fetchFromGitHub,
+  lib,
+  pytestCheckHook,
+  setuptools,
+  zstd-c,
+}:
+buildPythonPackage rec {
+  pname = "pyzstd";
+  version = "0.16.2";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "Rogdham";
+    repo = "pyzstd";
+    tag = version;
+    hash = "sha256-Az+0m1XUFxExBZK8bcjK54Zt2d5ZlAKRMZRdr7rPcss=";
+  };
+
+  postPatch = ''
+    # pyzst specifies setuptools<74 because 74+ drops `distutils.msvc9compiler`,
+    # required for Python 3.9 under Windows
+    substituteInPlace pyproject.toml \
+        --replace-fail '"setuptools>=64,<74"' '"setuptools"'
+  '';
+
+  nativeBuildInputs = [
+    setuptools
+  ];
+
+  build-system = [
+    setuptools
+  ];
+
+  buildInputs = [
+    zstd-c
+  ];
+
+  pypaBuildFlags = [
+    "--config-setting=--global-option=--dynamic-link-zstd"
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [
+    "pyzstd"
+  ];
+
+  meta = {
+    description = "Python bindings to Zstandard (zstd) compression library";
+    homepage = "https://pyzstd.readthedocs.io";
+    changelog = "https://github.com/Rogdham/pyzstd/blob/${version}/CHANGELOG.md";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [
+      MattSturgeon
+      PopeRigby
+    ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b98d245a8297..3ab83883e961 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -10988,6 +10988,10 @@ self: super: with self; {
 
   pyzipper = callPackage ../development/python-modules/pyzipper { };
 
+  pyzstd = callPackage ../development/python-modules/pyzstd {
+    zstd-c = pkgs.zstd;
+  };
+
   plac = callPackage ../development/python-modules/plac { };
 
   plaid-python = callPackage ../development/python-modules/plaid-python { };