diff --git a/pkgs/applications/emulators/wine/base.nix b/pkgs/applications/emulators/wine/base.nix
index a280b9d3e3d6..d30fe6039ec1 100644
--- a/pkgs/applications/emulators/wine/base.nix
+++ b/pkgs/applications/emulators/wine/base.nix
@@ -119,7 +119,6 @@ stdenv.mkDerivation ((lib.optionalAttrs (buildScript != null) {
   configureFlags = prevConfigFlags
     ++ lib.optionals supportFlags.waylandSupport [ "--with-wayland" ]
     ++ lib.optionals supportFlags.vulkanSupport [ "--with-vulkan" ]
-    ++ lib.optionals supportFlags.vkd3dSupport [ "--with-vkd3d" ]
     ++ lib.optionals (stdenv.isDarwin && !supportFlags.xineramaSupport) [ "--without-x" ];
 
   # Wine locates a lot of libraries dynamically through dlopen().  Add