diff --git a/pkgs/by-name/es/est-sfs/package.nix b/pkgs/by-name/es/est-sfs/package.nix
deleted file mode 100644
index a88578d99248..000000000000
--- a/pkgs/by-name/es/est-sfs/package.nix
+++ /dev/null
@@ -1,38 +0,0 @@
-{
-  lib,
-  stdenv,
-  fetchurl,
-  gsl,
-}:
-
-stdenv.mkDerivation rec {
-  pname = "est-sfs";
-  version = "2.03";
-
-  src = fetchurl {
-    url = "mirror://sourceforge/est-usfs/${pname}-release-${version}.tar.gz";
-    sha256 = "1hvamrgagz0xi89w8qafyd9mjrdpyika8zm22drddnjkp4sdj65n";
-  };
-
-  buildInputs = [ gsl ];
-
-  makeFlags = [
-    "CC=${stdenv.cc.targetPrefix}cc"
-  ];
-
-  installPhase = ''
-    mkdir -p $out/bin
-    mkdir -p $out/share/doc/${pname}
-    cp est-sfs $out/bin
-    cp est-sfs-documentation.pdf $out/share/doc/${pname}
-  '';
-
-  meta = with lib; {
-    homepage = "https://sourceforge.net/projects/est-usfs";
-    description = "Estimate the unfolded site frequency spectrum and ancestral states";
-    mainProgram = "est-sfs";
-    license = licenses.gpl3;
-    maintainers = [ maintainers.bzizou ];
-    platforms = platforms.all;
-  };
-}
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 6a2fff94b9e3..36a593f73422 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -624,6 +624,8 @@ mapAliases {
 
   erlang_language_platform = throw "erlang_language_platform has been renamed erlang-language-platform"; # added 2025-04-04
 
+  est-sfs = throw "'est-sfs' has been removed as it was unmaintained in Nixpkgs"; # Added 2025-05-18
+
   ethabi = throw "ethabi has been removed due to lack of maintainence upstream and no updates in Nixpkgs"; # Added 2024-07-16
   eww-wayland = lib.warnOnInstantiate "eww now can build for X11 and wayland simultaneously, so `eww-wayland` is deprecated, use the normal `eww` package instead." eww;