diff --git a/pkgs/development/python-modules/sparsediffpy/default.nix b/pkgs/development/python-modules/sparsediffpy/default.nix
new file mode 100644
index 000000000000..5b84d329f292
--- /dev/null
+++ b/pkgs/development/python-modules/sparsediffpy/default.nix
@@ -0,0 +1,59 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+
+  # build-system
+  cmake,
+  ninja,
+  numpy,
+  scikit-build-core,
+
+  # buildInputs
+  blas,
+}:
+
+buildPythonPackage (finalAttrs: {
+  pname = "sparsediffpy";
+  version = "0.3.0";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "SparseDifferentiation";
+    repo = "SparseDiffPy";
+    tag = "v${finalAttrs.version}";
+    # SparseDiffEngine is built from source and their cmake does not support finding it on the
+    # system. We fallback to using the git submodule approach for now.
+    fetchSubmodules = true;
+    hash = "sha256-4FiObnGIJSSH7BMkKS7y7rc4HYzDgMV7ym+wPZ/KHJ8=";
+  };
+
+  build-system = [
+    cmake
+    ninja
+    numpy
+    scikit-build-core
+  ];
+  dontUseCmakeConfigure = true;
+
+  buildInputs = [
+    blas
+  ];
+
+  dependencies = [
+    numpy
+  ];
+
+  pythonImportsCheck = [ "sparsediffpy" ];
+
+  # No tests
+  doCheck = false;
+
+  meta = {
+    description = "Python bindings for SparseDiffEngine, a C library for computing sparse Jacobians and Hessians";
+    homepage = "https://github.com/SparseDifferentiation/SparseDiffPy";
+    changelog = "https://github.com/SparseDifferentiation/SparseDiffPy/blob/${finalAttrs.src.tag}/RELEASES.md";
+    license = lib.licenses.asl20;
+    maintainers = with lib.maintainers; [ GaetanLepage ];
+  };
+})
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 569e979191bc..00be0656f960 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -18323,6 +18323,8 @@ self: super: with self; {
 
   sparse = callPackage ../development/python-modules/sparse { };
 
+  sparsediffpy = callPackage ../development/python-modules/sparsediffpy { };
+
   spatial-image = callPackage ../development/python-modules/spatial-image { };
 
   spatialmath-python = callPackage ../development/python-modules/spatialmath-python { };