diff --git a/pkgs/development/python-modules/nanobind/default.nix b/pkgs/development/python-modules/nanobind/default.nix
index b02f229ec136..66df98f351bc 100644
--- a/pkgs/development/python-modules/nanobind/default.nix
+++ b/pkgs/development/python-modules/nanobind/default.nix
@@ -1,31 +1,37 @@
 {
   lib,
   buildPythonPackage,
-  pythonOlder,
   fetchFromGitHub,
+  pythonOlder,
+
+  # build-system
   cmake,
-  eigen,
   ninja,
-  scikit-build,
+  pathspec,
+  scikit-build-core,
+
+  # dependencies
+  eigen,
+
+  # tests
   pytestCheckHook,
   numpy,
   scipy,
   torch,
+  tensorflow-bin,
   jax,
   jaxlib,
-  tensorflow,
-  setuptools,
 }:
 buildPythonPackage rec {
   pname = "nanobind";
-  version = "2.0.0";
+  version = "2.1.0";
   pyproject = true;
 
   src = fetchFromGitHub {
     owner = "wjakob";
     repo = "nanobind";
     rev = "refs/tags/v${version}";
-    hash = "sha256-yDFrhSIWywWw7ri5aHRPigi9ujDeazpJa4AVrkLx5BI=";
+    hash = "sha256-AO/EHx2TlXidalhPb+xuUchaek4ki7fDExu2foBgUp0=";
     fetchSubmodules = true;
   };
 
@@ -34,11 +40,11 @@ buildPythonPackage rec {
   build-system = [
     cmake
     ninja
-    scikit-build
-    setuptools
+    pathspec
+    scikit-build-core
   ];
 
-  buildInputs = [ eigen ];
+  dependencies = [ eigen ];
   dontUseCmakeBuildDir = true;
 
   preCheck = ''
@@ -51,7 +57,7 @@ buildPythonPackage rec {
     numpy
     scipy
     torch
-    tensorflow
+    tensorflow-bin
     jax
     jaxlib
   ];