diff --git a/pkgs/development/interpreters/python/cpython/default.nix b/pkgs/development/interpreters/python/cpython/default.nix
index 2c754ba43fc7..2f5342efd403 100644
--- a/pkgs/development/interpreters/python/cpython/default.nix
+++ b/pkgs/development/interpreters/python/cpython/default.nix
@@ -208,10 +208,16 @@ let
   nativeBuildInputs = [
     nukeReferences
   ]
-  ++ optionals (!stdenv.hostPlatform.isDarwin && !withMinimalDeps) [
-    autoconf-archive # needed for AX_CHECK_COMPILE_FLAG
-    autoreconfHook
-  ]
+  ++
+    optionals
+      (
+        (!stdenv.hostPlatform.isDarwin && !withMinimalDeps)
+        || (stdenv.hostPlatform != stdenv.buildPlatform && stdenv.hostPlatform.isFreeBSD)
+      )
+      [
+        autoconf-archive # needed for AX_CHECK_COMPILE_FLAG
+        autoreconfHook
+      ]
   ++
     optionals ((!stdenv.hostPlatform.isDarwin || passthru.pythonAtLeast "3.14") && !withMinimalDeps)
       [
diff --git a/pkgs/development/interpreters/python/cpython/freebsd-cross.patch b/pkgs/development/interpreters/python/cpython/freebsd-cross.patch
index 71b45bfead27..9ad1d20899f0 100644
--- a/pkgs/development/interpreters/python/cpython/freebsd-cross.patch
+++ b/pkgs/development/interpreters/python/cpython/freebsd-cross.patch
@@ -1,6 +1,6 @@
 --- a/configure.ac	2024-06-07 09:17:50.608162031 -0700
 +++ b/configure.ac	2024-06-07 09:45:59.844518241 -0700
-@@ -554,6 +554,9 @@
+@@ -339,6 +339,9 @@
  	*-*-wasi)
  	    ac_sys_system=WASI
  	    ;;
@@ -10,7 +10,7 @@
  	*)
  		# for now, limit cross builds to known configurations
  		MACHDEP="unknown"
-@@ -614,6 +617,9 @@
+@@ -780,6 +783,9 @@
  	wasm32-*-* | wasm64-*-*)
  		_host_cpu=$host_cpu
  		;;