diff --git a/pkgs/development/python-modules/mhcflurry/default.nix b/pkgs/development/python-modules/mhcflurry/default.nix
index 6ade4b8ecb2e..2b2a7c9fcabb 100644
--- a/pkgs/development/python-modules/mhcflurry/default.nix
+++ b/pkgs/development/python-modules/mhcflurry/default.nix
@@ -7,7 +7,6 @@
 , nose
 , pandas
 , pytestCheckHook
-, pythonRelaxDepsHook
 , pyyaml
 , scikit-learn
 , tensorflow
@@ -16,23 +15,16 @@
 
 buildPythonPackage rec {
   pname = "mhcflurry";
-  version = "2.0.6";
+  version = "2.1.0";
   format = "setuptools";
 
   src = fetchFromGitHub {
     owner = "openvax";
     repo = pname;
     rev = "refs/tags/v${version}";
-    hash = "sha256-Cr7L6uo6Kc1PSeG5nK6zQSD7eeCFcUJUzhsX+waz7og=";
+    hash = "sha256-VyPHcNlZYgNJZb2UBFX55x+nE0GnHixkcsiTNjDCju0=";
   };
 
-  nativeBuildInputs = [ pythonRelaxDepsHook ];
-
-  pythonRemoveDeps = [
-    # See https://github.com/openvax/mhcflurry/issues/216.
-    "np-utils"
-  ];
-
   # keras and tensorflow are not in the official setup.py requirements but are required for the CLI utilities to run.
   propagatedBuildInputs = [
     appdirs
@@ -75,10 +67,6 @@ buildPythonPackage rec {
     "test_run_serial"
     "test_speed_allele_specific"
     "test_speed_pan_allele"
-
-    # See https://github.com/openvax/mhcflurry/issues/217
-    "test_more"
-    "test_small"
   ];
 
   disabledTestPaths = [