diff --git a/pkgs/development/python-modules/bme280spi/default.nix b/pkgs/development/python-modules/bme280spi/default.nix
new file mode 100644
index 000000000000..a7a1e0fb920e
--- /dev/null
+++ b/pkgs/development/python-modules/bme280spi/default.nix
@@ -0,0 +1,32 @@
+{ lib
+, buildPythonPackage
+, pythonOlder
+, fetchPypi
+, spidev
+}:
+
+buildPythonPackage rec {
+  pname = "bme280spi";
+  version = "0.2.0";
+
+  disabled = pythonOlder "3.8";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "51682acefda6f29eaaf9f37815edbfdd48ef0e9f1509419eceafe7b440eddc6e";
+  };
+
+  propagatedBuildInputs = [
+    spidev
+  ];
+
+  # no tests implemented
+  doCheck = false;
+
+  meta = with lib; {
+    description = "Library for BME280 sensor through spidev";
+    homepage = "https://github.com/Kuzj/bme280spi";
+    license = licenses.mit;
+    maintainers = with maintainers; [ dotlambda ];
+  };
+}
diff --git a/pkgs/development/python-modules/i2csense/default.nix b/pkgs/development/python-modules/i2csense/default.nix
new file mode 100644
index 000000000000..475e77c21841
--- /dev/null
+++ b/pkgs/development/python-modules/i2csense/default.nix
@@ -0,0 +1,35 @@
+{ lib
+, buildPythonPackage
+, fetchPypi
+, smbus-cffi
+}:
+
+buildPythonPackage rec {
+  pname = "i2csense";
+  version = "0.0.4";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "6f9c0a37d971e5b8a60c54982bd580cff84bf94fedc08c097e603a8e5609c33f";
+  };
+
+  propagatedBuildInputs = [
+    smbus-cffi
+  ];
+
+  # no tests implemented
+  doCheck = false;
+
+  pythonImportsCheck = [
+    "i2csense.bme280"
+    "i2csense.bh1750"
+    "i2csense.htu21d"
+  ];
+
+  meta = with lib; {
+    description = "A library to handle i2c sensors with the Raspberry Pi";
+    homepage = "https://github.com/azogue/i2csense";
+    license = licenses.mit;
+    maintainers = with maintainers; [ dotlambda ];
+  };
+}
diff --git a/pkgs/servers/home-assistant/component-packages.nix b/pkgs/servers/home-assistant/component-packages.nix
index c7aeb4253106..03138da199de 100644
--- a/pkgs/servers/home-assistant/component-packages.nix
+++ b/pkgs/servers/home-assistant/component-packages.nix
@@ -83,7 +83,7 @@
     "bbb_gpio" = ps: with ps; [ ]; # missing inputs: Adafruit_BBIO
     "bbox" = ps: with ps; [ ]; # missing inputs: pybbox
     "beewi_smartclim" = ps: with ps; [ ]; # missing inputs: beewi_smartclim
-    "bh1750" = ps: with ps; [ smbus-cffi ]; # missing inputs: i2csense
+    "bh1750" = ps: with ps; [ i2csense smbus-cffi ];
     "binary_sensor" = ps: with ps; [ ];
     "bitcoin" = ps: with ps; [ blockchain ];
     "bizkaibus" = ps: with ps; [ bizkaibus ];
@@ -98,7 +98,7 @@
     "bluesound" = ps: with ps; [ xmltodict ];
     "bluetooth_le_tracker" = ps: with ps; [ pygatt ];
     "bluetooth_tracker" = ps: with ps; [ bt-proximity pybluez ];
-    "bme280" = ps: with ps; [ smbus-cffi ]; # missing inputs: bme280spi i2csense
+    "bme280" = ps: with ps; [ bme280spi i2csense smbus-cffi ];
     "bme680" = ps: with ps; [ bme680 smbus-cffi ];
     "bmp280" = ps: with ps; [ ]; # missing inputs: RPi.GPIO adafruit-circuitpython-bmp280
     "bmw_connected_drive" = ps: with ps; [ bimmer-connected ];
@@ -382,7 +382,7 @@
     "hp_ilo" = ps: with ps; [ python-hpilo ];
     "html5" = ps: with ps; [ aiohttp-cors pywebpush ];
     "http" = ps: with ps; [ aiohttp-cors ];
-    "htu21d" = ps: with ps; [ smbus-cffi ]; # missing inputs: i2csense
+    "htu21d" = ps: with ps; [ i2csense smbus-cffi ];
     "huawei_lte" = ps: with ps; [ huawei-lte-api stringcase url-normalize ];
     "hue" = ps: with ps; [ aiohue ];
     "huisbaasje" = ps: with ps; [ huisbaasje-client ];
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 7d8c0c20c42b..260bc92d5bb9 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1280,6 +1280,8 @@ in {
 
   blurhash = callPackage ../development/python-modules/blurhash { };
 
+  bme280spi = callPackage ../development/python-modules/bme280spi { };
+
   bme680 = callPackage ../development/python-modules/bme680 { };
 
   bokeh = callPackage ../development/python-modules/bokeh { };
@@ -3876,6 +3878,8 @@ in {
     inherit (pkgs) i2c-tools;
   };
 
+  i2csense = callPackage ../development/python-modules/i2csense { };
+
   i3ipc = callPackage ../development/python-modules/i3ipc { };
 
   i3-py = callPackage ../development/python-modules/i3-py { };