diff --git a/pkgs/development/python-modules/brian2/0001-remove-invalidxyz.patch b/pkgs/development/python-modules/brian2/0001-remove-invalidxyz.patch
new file mode 100644
index 000000000000..435e3d12cacc
--- /dev/null
+++ b/pkgs/development/python-modules/brian2/0001-remove-invalidxyz.patch
@@ -0,0 +1,27 @@
+From dbf0af29767629def355427cf63410158708c632 Mon Sep 17 00:00:00 2001
+From: Bot_wxt1221 <3264117476@qq.com>
+Date: Wed, 13 Nov 2024 21:15:04 +0800
+Subject: [PATCH] Update test_codegen.py
+
+---
+ brian2/tests/test_codegen.py | 7 -------
+ 1 file changed, 7 deletions(-)
+
+diff --git a/brian2/tests/test_codegen.py b/brian2/tests/test_codegen.py
+index fdc03cdf2..6f7ae50bd 100644
+--- a/brian2/tests/test_codegen.py
++++ b/brian2/tests/test_codegen.py
+@@ -589,13 +589,6 @@ def test_cpp_flags_support():
+     _, compile_args = get_compiler_and_args()
+     assert compile_args == prefs["codegen.cpp.extra_compile_args"]
+ 
+-    # Should never be supported and raise a warning
+-    prefs["codegen.cpp.extra_compile_args"] = ["-invalidxyz"]
+-    with catch_logs() as l:
+-        _, compile_args = get_compiler_and_args()
+-    assert len(l) == 1 and l[0][0] == "WARNING"
+-    assert compile_args == []
+-
+     prefs["codegen.cpp.extra_compile_args"] = old_prefs
+ 
+ 
diff --git a/pkgs/development/python-modules/brian2/default.nix b/pkgs/development/python-modules/brian2/default.nix
index a0021585cfc5..d9f23ec574b1 100644
--- a/pkgs/development/python-modules/brian2/default.nix
+++ b/pkgs/development/python-modules/brian2/default.nix
@@ -9,8 +9,12 @@
   setuptools,
   sympy,
   pytest,
+  pythonOlder,
   pytest-xdist,
+  setuptools-scm,
   python,
+  scipy,
+  fetchpatch,
 }:
 
 buildPythonPackage rec {
@@ -18,12 +22,33 @@ buildPythonPackage rec {
   version = "2.7.1";
   pyproject = true;
 
+  # https://github.com/python/cpython/issues/117692
+  disabled = pythonOlder "3.12";
+
   src = fetchPypi {
     inherit pname version;
     hash = "sha256-mp1xo6ooYm21s6FYcegQdsHmVgH81usV9IfIM0GM7lc=";
   };
 
-  build-system = [ setuptools ];
+  patches = [
+    (fetchpatch {
+      url = "https://github.com/brian-team/brian2/commit/8ed663cafde42cbe2e0171cb19d2217e01676d20.patch";
+      hash = "sha256-+s5SJdJmsnee3sWhaj/jwf8RXkfMrLp0aTWF52jLdqU=";
+    })
+    ./0001-remove-invalidxyz.patch # invalidxyz are reported as error so I remove it
+  ];
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail "numpy>=2.0.0rc1" "numpy"
+
+    substituteInPlace brian2/codegen/cpp_prefs.py \
+      --replace-fail "distutils" "setuptools._distutils"
+  '';
+
+  build-system = [
+    setuptools-scm
+  ];
 
   dependencies = [
     cython
@@ -32,6 +57,7 @@ buildPythonPackage rec {
     pyparsing
     setuptools
     sympy
+    scipy
   ];
 
   nativeCheckInputs = [
@@ -47,10 +73,10 @@ buildPythonPackage rec {
     runHook postCheck
   '';
 
-  meta = with lib; {
+  meta = {
     description = "Clock-driven simulator for spiking neural networks";
     homepage = "https://briansimulator.org/";
-    license = licenses.cecill21;
-    maintainers = with maintainers; [ jiegec ];
+    license = lib.licenses.cecill21;
+    maintainers = with lib.maintainers; [ jiegec ];
   };
 }