diff --git a/pkgs/applications/misc/orca/fix-paths.patch b/pkgs/applications/misc/orca/fix-paths.patch
deleted file mode 100644
index 45ae4b827ba5..000000000000
--- a/pkgs/applications/misc/orca/fix-paths.patch
+++ /dev/null
@@ -1,88 +0,0 @@
-diff --git a/src/orca/debug.py b/src/orca/debug.py
-index b7e11ea60..9ab996765 100644
---- a/src/orca/debug.py
-+++ b/src/orca/debug.py
-@@ -447,7 +447,7 @@ def traceit(frame, event, arg):
-     return traceit
- 
- def getOpenFDCount(pid):
--    procs = subprocess.check_output([ 'lsof', '-w', '-Ff', '-p', str(pid)])
-+    procs = subprocess.check_output([ '@lsof@', '-w', '-Ff', '-p', str(pid)])
-     procs = procs.decode('UTF-8').split('\n')
-     files = list(filter(lambda s: s and s[0] == 'f' and s[1:].isdigit(), procs))
- 
-@@ -465,7 +465,7 @@ def getCmdline(pid):
-     return cmdline
- 
- def pidOf(procName):
--    openFile = subprocess.Popen(f'pgrep {procName}',
-+    openFile = subprocess.Popen(f'@pgrep@ {procName}',
-                                 shell=True,
-                                 stdout=subprocess.PIPE).stdout
-     pids = openFile.read()
-diff --git a/src/orca/orca.py b/src/orca/orca.py
-index d4e89f918..bb3e6cc1d 100644
---- a/src/orca/orca.py
-+++ b/src/orca/orca.py
-@@ -312,7 +312,7 @@ def updateKeyMap(keyboardEvent):
- 
- def _setXmodmap(xkbmap):
-     """Set the keyboard map using xkbcomp."""
--    p = subprocess.Popen(['xkbcomp', '-w0', '-', os.environ['DISPLAY']],
-+    p = subprocess.Popen(['@xkbcomp@', '-w0', '-', os.environ['DISPLAY']],
-         stdin=subprocess.PIPE, stdout=None, stderr=None)
-     p.communicate(xkbmap)
- 
-@@ -389,7 +389,7 @@ def _storeXmodmap(keyList):
-     """
- 
-     global _originalXmodmap
--    _originalXmodmap = subprocess.check_output(['xkbcomp', os.environ['DISPLAY'], '-'])
-+    _originalXmodmap = subprocess.check_output(['@xkbcomp@', os.environ['DISPLAY'], '-'])
- 
- def _restoreXmodmap(keyList=[]):
-     """Restore the original xmodmap values for the keys in keyList.
-@@ -404,7 +404,7 @@ def _restoreXmodmap(keyList=[]):
- 
-     global _capsLockCleared
-     _capsLockCleared = False
--    p = subprocess.Popen(['xkbcomp', '-w0', '-', os.environ['DISPLAY']],
-+    p = subprocess.Popen(['@xkbcomp@', '-w0', '-', os.environ['DISPLAY']],
-         stdin=subprocess.PIPE, stdout=None, stderr=None)
-     p.communicate(_originalXmodmap)
- 
-diff --git a/src/orca/orca_bin.py.in b/src/orca/orca_bin.py.in
-index 9d64af948..ca9c9e083 100644
---- a/src/orca/orca_bin.py.in
-+++ b/src/orca/orca_bin.py.in
-@@ -65,7 +65,7 @@ class ListApps(argparse.Action):
-                 name = "[DEAD]"
- 
-             try:
--                cmdline = subprocess.getoutput('cat /proc/%s/cmdline' % pid)
-+                cmdline = subprocess.getoutput('@cat@ /proc/%s/cmdline' % pid)
-             except Exception:
-                 cmdline = '(exception encountered)'
-             else:
-@@ -198,7 +198,7 @@ def inGraphicalDesktop():
- def otherOrcas():
-     """Returns the pid of any other instances of Orca owned by this user."""
- 
--    openFile = subprocess.Popen('pgrep -u %s -x orca' % os.getuid(),
-+    openFile = subprocess.Popen('@pgrep@ -u %s -x orca' % os.getuid(),
-                                 shell=True,
-                                 stdout=subprocess.PIPE).stdout
-     pids = openFile.read()
-diff --git a/src/orca/script_utilities.py b/src/orca/script_utilities.py
-index ed8b155e4..0436cca42 100644
---- a/src/orca/script_utilities.py
-+++ b/src/orca/script_utilities.py
-@@ -144,7 +144,7 @@ class Utilities:
-             return ""
- 
-         try:
--            cmdline = subprocess.getoutput(f"cat /proc/{pid}/cmdline")
-+            cmdline = subprocess.getoutput(f"@cat@ /proc/{pid}/cmdline")
-         except Exception:
-             return ""
- 
diff --git a/pkgs/by-name/or/orca/fix-paths.patch b/pkgs/by-name/or/orca/fix-paths.patch
new file mode 100644
index 000000000000..5f5feacb33a5
--- /dev/null
+++ b/pkgs/by-name/or/orca/fix-paths.patch
@@ -0,0 +1,75 @@
+diff --git a/src/orca/debug.py b/src/orca/debug.py
+index eb939a236..4e4db2e84 100644
+--- a/src/orca/debug.py
++++ b/src/orca/debug.py
+@@ -522,7 +522,7 @@ def traceit(frame, event, arg):
+     return traceit
+ 
+ def getOpenFDCount(pid):
+-    procs = subprocess.check_output([ 'lsof', '-w', '-Ff', '-p', str(pid)])
++    procs = subprocess.check_output([ '@lsof@', '-w', '-Ff', '-p', str(pid)])
+     procs = procs.decode('UTF-8').split('\n')
+     files = list(filter(lambda s: s and s[0] == 'f' and s[1:].isdigit(), procs))
+ 
+@@ -540,7 +540,7 @@ def getCmdline(pid):
+     return cmdline
+ 
+ def pidOf(procName):
+-    openFile = subprocess.Popen(f'pgrep {procName}',
++    openFile = subprocess.Popen(f'@pgrep@ {procName}',
+                                 shell=True,
+                                 stdout=subprocess.PIPE).stdout
+     pids = openFile.read()
+diff --git a/src/orca/orca_bin.py.in b/src/orca/orca_bin.py.in
+index c6f99de14..2370204f3 100755
+--- a/src/orca/orca_bin.py.in
++++ b/src/orca/orca_bin.py.in
+@@ -62,7 +62,7 @@ class ListApps(argparse.Action):
+                 name = "[DEAD]"
+ 
+             try:
+-                cmdline = subprocess.getoutput('cat /proc/%s/cmdline' % pid)
++                cmdline = subprocess.getoutput('@cat@ /proc/%s/cmdline' % pid)
+             except Exception:
+                 cmdline = '(exception encountered)'
+             else:
+@@ -195,7 +195,7 @@ def inGraphicalDesktop():
+ def otherOrcas():
+     """Returns the pid of any other instances of Orca owned by this user."""
+ 
+-    openFile = subprocess.Popen('pgrep -u %s -x orca' % os.getuid(),
++    openFile = subprocess.Popen('@pgrep@ -u %s -x orca' % os.getuid(),
+                                 shell=True,
+                                 stdout=subprocess.PIPE).stdout
+     pids = openFile.read()
+diff --git a/src/orca/orca_modifier_manager.py b/src/orca/orca_modifier_manager.py
+index c45cd4a5b..3f2ec59f0 100644
+--- a/src/orca/orca_modifier_manager.py
++++ b/src/orca/orca_modifier_manager.py
+@@ -115,7 +115,7 @@ class OrcaModifierManager:
+         debug.printMessage(debug.LEVEL_INFO, msg, True)
+ 
+         self.unset_orca_modifiers(reason)
+-        self._original_xmodmap = subprocess.check_output(['xkbcomp', os.environ['DISPLAY'], '-'])
++        self._original_xmodmap = subprocess.check_output(['@xkbcomp@', os.environ['DISPLAY'], '-'])
+         self._create_orca_xmodmap()
+ 
+     def update_key_map(self, keyboard_event):
+@@ -162,7 +162,7 @@ class OrcaModifierManager:
+             return
+ 
+         self._caps_lock_cleared = False
+-        p = subprocess.Popen(['xkbcomp', '-w0', '-', os.environ['DISPLAY']],
++        p = subprocess.Popen(['@xkbcomp@', '-w0', '-', os.environ['DISPLAY']],
+             stdin=subprocess.PIPE, stdout=None, stderr=None)
+         p.communicate(self._original_xmodmap)
+ 
+@@ -223,7 +223,7 @@ class OrcaModifierManager:
+         if modified:
+             msg = "ORCA MODIFIER MANAGER: Updating xmodmap"
+             debug.printMessage(debug.LEVEL_INFO, msg, True)
+-            p = subprocess.Popen(['xkbcomp', '-w0', '-', os.environ['DISPLAY']],
++            p = subprocess.Popen(['@xkbcomp@', '-w0', '-', os.environ['DISPLAY']],
+                 stdin=subprocess.PIPE, stdout=None, stderr=None)
+             p.communicate(bytes('\n'.join(lines), 'UTF-8'))
+         else:
diff --git a/pkgs/applications/misc/orca/default.nix b/pkgs/by-name/or/orca/package.nix
similarity index 85%
rename from pkgs/applications/misc/orca/default.nix
rename to pkgs/by-name/or/orca/package.nix
index dcb578dd5678..2ae6a649c84c 100644
--- a/pkgs/applications/misc/orca/default.nix
+++ b/pkgs/by-name/or/orca/package.nix
@@ -1,24 +1,20 @@
 { lib
 , pkg-config
 , fetchurl
-, buildPythonApplication
-, autoreconfHook
+, meson
+, ninja
 , wrapGAppsHook
 , gobject-introspection
 , gettext
 , yelp-tools
 , itstool
-, python
-, pygobject3
+, python3
 , gtk3
 , gnome
 , substituteAll
 , at-spi2-atk
 , at-spi2-core
-, pyatspi
 , dbus
-, dbus-python
-, pyxdg
 , xkbcomp
 , procps
 , lsof
@@ -27,20 +23,18 @@
 , speechd
 , brltty
 , liblouis
-, setproctitle
 , gst_all_1
-, gst-python
 }:
 
-buildPythonApplication rec {
+python3.pkgs.buildPythonApplication rec {
   pname = "orca";
-  version = "45.2";
+  version = "46.1";
 
   format = "other";
 
   src = fetchurl {
     url = "mirror://gnome/sources/${pname}/${lib.versions.major version}/${pname}-${version}.tar.xz";
-    sha256 = "8PLFeaW+7f5WU7x/4kSBxNaqxd0fccHnoghZXzx473Y=";
+    hash = "sha256-z2deNQwYrA+ilDbGVZ0dqXX3///vqAjr5HbY+enRERQ=";
   };
 
   patches = [
@@ -54,7 +48,8 @@ buildPythonApplication rec {
   ];
 
   nativeBuildInputs = [
-    autoreconfHook
+    meson
+    ninja
     wrapGAppsHook
     pkg-config
     gettext
@@ -63,13 +58,13 @@ buildPythonApplication rec {
     gobject-introspection
   ];
 
-  pythonPath = [
+  pythonPath = with python3.pkgs; [
     pygobject3
-    pyatspi
     dbus-python
     pyxdg
     brltty
     liblouis
+    psutil
     speechd
     gst-python
     setproctitle
@@ -78,7 +73,7 @@ buildPythonApplication rec {
   strictDeps = false;
 
   buildInputs = [
-    python
+    python3
     gtk3
     at-spi2-atk
     at-spi2-core
@@ -89,6 +84,12 @@ buildPythonApplication rec {
     gst_all_1.gst-plugins-good
   ];
 
+  dontWrapGApps = true; # Prevent double wrapping
+
+  preFixup = ''
+    makeWrapperArgs+=("''${gappsWrapperArgs[@]}")
+  '';
+
   passthru = {
     updateScript = gnome.updateScript {
       packageName = pname;
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 040fa763bf61..9eeca4e65e44 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -33748,10 +33748,6 @@ with pkgs;
 
   oranda = callPackage ../applications/misc/oranda { };
 
-  orca = python3Packages.callPackage ../applications/misc/orca {
-    inherit pkg-config;
-  };
-
   orca-c = callPackage ../applications/audio/orca-c { };
 
   organicmaps = qt6Packages.callPackage ../applications/misc/organicmaps { };