diff --git a/pkgs/development/python-modules/podman/default.nix b/pkgs/development/python-modules/podman/default.nix
new file mode 100644
index 000000000000..6d46b97e384e
--- /dev/null
+++ b/pkgs/development/python-modules/podman/default.nix
@@ -0,0 +1,76 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, fixtures
+, pytestCheckHook
+, pythonOlder
+, pyxdg
+, requests
+, requests-mock
+, setuptools
+, tomli
+, urllib3
+, wheel
+}:
+
+buildPythonPackage rec {
+  pname = "podman";
+  version = "4.6.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.7";
+
+  src = fetchFromGitHub {
+    owner = "containers";
+    repo = "podman-py";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-76mLgkQgYbm04bj1VX7SC/kW8JEbYjbK3x6Xb612wnk=";
+  };
+
+  nativeBuildInputs = [
+    setuptools
+    wheel
+  ];
+
+  propagatedBuildInputs = [
+    pyxdg
+    requests
+    tomli
+    urllib3
+  ];
+
+  nativeCheckInputs = [
+    fixtures
+    pytestCheckHook
+    requests-mock
+  ];
+
+  preCheck = ''
+    export HOME=$(mktemp -d)
+  '';
+
+  pythonImportsCheck = [
+    "podman"
+  ];
+
+  disabledTests = [
+    # Integration tests require a running container setup
+    "AdapterIntegrationTest"
+    "ContainersIntegrationTest"
+    "ImagesIntegrationTest"
+    "ManifestsIntegrationTest"
+    "NetworksIntegrationTest"
+    "PodsIntegrationTest"
+    "SecretsIntegrationTest"
+    "SystemIntegrationTest"
+    "VolumesIntegrationTest"
+  ];
+
+  meta = with lib; {
+    description = "Python bindings for Podman's RESTful API";
+    homepage = "https://github.com/containers/podman-py";
+    changelog = "https://github.com/containers/podman-py/releases/tag/v${version}";
+    license = licenses.asl20;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f89cd0192fbd..e0d755933ffe 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8539,6 +8539,8 @@ self: super: with self; {
 
   podcats = callPackage ../development/python-modules/podcats { };
 
+  podman = callPackage ../development/python-modules/podman { };
+
   poetry-core = callPackage ../development/python-modules/poetry-core { };
 
   poetry-dynamic-versioning = callPackage ../development/python-modules/poetry-dynamic-versioning { };