diff --git a/pkgs/by-name/gn/gnumake42/package.nix b/pkgs/by-name/gn/gnumake42/package.nix
index dc323447af9b..2d7b0394a004 100644
--- a/pkgs/by-name/gn/gnumake42/package.nix
+++ b/pkgs/by-name/gn/gnumake42/package.nix
@@ -33,17 +33,7 @@ stdenv.mkDerivation rec {
   nativeBuildInputs = lib.optionals guileSupport [ pkg-config ];
   buildInputs = lib.optionals guileSupport [ guile ];
 
-  configureFlags =
-    lib.optional guileSupport "--with-guile"
-
-    # Make uses this test to decide whether it should keep track of
-    # subseconds. Apple made this possible with APFS and macOS 10.13.
-    # However, we still support macOS 10.11 and 10.12. Binaries built
-    # in Nixpkgs will be unable to use futimens to set mtime less than
-    # a second. So, tell Make to ignore nanoseconds in mtime here by
-    # overriding the autoconf test for the struct.
-    # See https://github.com/NixOS/nixpkgs/issues/51221 for discussion.
-    ++ lib.optional stdenv.hostPlatform.isDarwin "ac_cv_struct_st_mtim_nsec=no";
+  configureFlags = lib.optional guileSupport "--with-guile";
 
   outputs = [
     "out"
diff --git a/pkgs/by-name/in/inetutils/package.nix b/pkgs/by-name/in/inetutils/package.nix
index 53c8a2de9bc4..ddd96ffb3042 100644
--- a/pkgs/by-name/in/inetutils/package.nix
+++ b/pkgs/by-name/in/inetutils/package.nix
@@ -39,12 +39,6 @@ stdenv.mkDerivation rec {
     libxcrypt
   ];
 
-  env = lib.optionalAttrs stdenv.hostPlatform.isDarwin {
-    # This is a temporary workaround for missing headers in the 10.12 SDK to avoid a mass rebuild.
-    # A commit to revert this change will be included in the fix PR targeting staging.
-    NIX_CFLAGS_COMPILE = "-Wno-error=implicit-function-declaration";
-  };
-
   # Don't use help2man if cross-compiling
   # https://lists.gnu.org/archive/html/bug-sed/2017-01/msg00001.html
   # https://git.congatec.com/yocto/meta-openembedded/blob/3402bfac6b595c622e4590a8ff5eaaa854e2a2a3/meta-networking/recipes-connectivity/inetutils/inetutils_1.9.1.bb#L44
diff --git a/pkgs/development/libraries/libepoxy/default.nix b/pkgs/development/libraries/libepoxy/default.nix
index 5ff8055cedee..fcf8e65c4de5 100644
--- a/pkgs/development/libraries/libepoxy/default.nix
+++ b/pkgs/development/libraries/libepoxy/default.nix
@@ -37,10 +37,6 @@ stdenv.mkDerivation (finalAttrs: {
   + lib.optionalString stdenv.hostPlatform.isDarwin ''
     substituteInPlace test/meson.build \
       --replace "[ 'cgl_epoxy_api', [ 'cgl_epoxy_api.c' ] ]," ""
-  ''
-  + lib.optionalString (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64) ''
-    substituteInPlace test/meson.build \
-      --replace "[ 'cgl_core', [ 'cgl_core.c' ] ]," ""
   '';
 
   outputs = [ "out" "dev" ];
diff --git a/pkgs/development/libraries/tk/generic.nix b/pkgs/development/libraries/tk/generic.nix
index 73d37d55db93..d3a92589e474 100644
--- a/pkgs/development/libraries/tk/generic.nix
+++ b/pkgs/development/libraries/tk/generic.nix
@@ -1,5 +1,5 @@
 { stdenv, lib, src, pkg-config, tcl, libXft, zip, zlib, patches ? []
-, enableAqua ? stdenv.hostPlatform.isDarwin, darwin
+, enableAqua ? stdenv.hostPlatform.isDarwin
 , ... }:
 
 tcl.mkTclDerivation {
@@ -21,10 +21,6 @@ tcl.mkTclDerivation {
     for file in $(find library/demos/. -type f ! -name "*.*"); do
       substituteInPlace $file --replace "exec wish" "exec $out/bin/wish"
     done
-  ''
-  + lib.optionalString (stdenv.hostPlatform.isDarwin && lib.versionOlder stdenv.hostPlatform.darwinMinVersion "11") ''
-    substituteInPlace unix/configure* \
-      --replace-fail " -weak_framework UniformTypeIdentifiers" ""
   '';
 
   postInstall = ''
@@ -62,11 +58,7 @@ tcl.mkTclDerivation {
 
   propagatedBuildInputs = [
     libXft
-  ] ++ lib.optionals enableAqua ([
-    darwin.apple_sdk.frameworks.Cocoa
-  ] ++ lib.optionals (lib.versionAtLeast stdenv.hostPlatform.darwinMinVersion "11") [
-    darwin.apple_sdk.frameworks.UniformTypeIdentifiers
-  ]);
+  ];
 
   enableParallelBuilding = true;
 
diff --git a/pkgs/development/tools/build-managers/gnumake/default.nix b/pkgs/development/tools/build-managers/gnumake/default.nix
index e5fc56c2249b..81cfedf6f604 100644
--- a/pkgs/development/tools/build-managers/gnumake/default.nix
+++ b/pkgs/development/tools/build-managers/gnumake/default.nix
@@ -43,17 +43,7 @@ stdenv.mkDerivation rec {
   ];
   buildInputs = lib.optionals guileEnabled [ guile ];
 
-  configureFlags =
-    lib.optional guileEnabled "--with-guile"
-
-    # Make uses this test to decide whether it should keep track of
-    # subseconds. Apple made this possible with APFS and macOS 10.13.
-    # However, we still support macOS 10.11 and 10.12. Binaries built
-    # in Nixpkgs will be unable to use futimens to set mtime less than
-    # a second. So, tell Make to ignore nanoseconds in mtime here by
-    # overriding the autoconf test for the struct.
-    # See https://github.com/NixOS/nixpkgs/issues/51221 for discussion.
-    ++ lib.optional stdenv.hostPlatform.isDarwin "ac_cv_struct_st_mtim_nsec=no";
+  configureFlags = lib.optional guileEnabled "--with-guile";
 
   outputs = [
     "out"