diff --git a/pkgs/development/python-modules/wasmtime/default.nix b/pkgs/development/python-modules/wasmtime/default.nix
index 0d6385e2d5ee..a45f7150c493 100644
--- a/pkgs/development/python-modules/wasmtime/default.nix
+++ b/pkgs/development/python-modules/wasmtime/default.nix
@@ -10,8 +10,13 @@
   setuptools-git-versioning,
   setuptools,
   writableTmpDirAsHomeHook,
+  stdenvNoCC,
 }:
-
+let
+  inherit (stdenvNoCC) targetPlatform;
+  systemDir = "${targetPlatform.parsed.kernel.name}-${targetPlatform.parsed.cpu.name}";
+  libExt = targetPlatform.extensions.sharedLibrary;
+in
 buildPythonPackage (finalAttrs: {
   pname = "wasmtime";
   version = "44.0.0";
@@ -35,9 +40,8 @@ buildPythonPackage (finalAttrs: {
     sed -i '/^backend-path = \[/,/^\]/d' pyproject.toml
 
     # Use nixpkgs' wasmtime instead of downloading prebuilt C API artifacts.
-    mkdir -p wasmtime/linux-x86_64 wasmtime/linux-aarch64
-    ln -s ${lib.getLib pkgs.wasmtime}/lib/libwasmtime.so wasmtime/linux-x86_64/_libwasmtime.so
-    ln -s ${lib.getLib pkgs.wasmtime}/lib/libwasmtime.so wasmtime/linux-aarch64/_libwasmtime.so
+    mkdir -p wasmtime/${systemDir}
+    ln -s ${lib.getLib pkgs.wasmtime}/lib/libwasmtime${libExt} wasmtime/${systemDir}/_libwasmtime${libExt}
   '';
 
   build-system = [
@@ -49,10 +53,8 @@ buildPythonPackage (finalAttrs: {
 
   postInstall = ''
     # Ensure the installed module can find the shared library at runtime
-    mkdir -p "$out/${python.sitePackages}/wasmtime/linux-x86_64"
-    mkdir -p "$out/${python.sitePackages}/wasmtime/linux-aarch64"
-    ln -sf ${lib.getLib pkgs.wasmtime}/lib/libwasmtime.so "$out/${python.sitePackages}/wasmtime/linux-x86_64/_libwasmtime.so"
-    ln -sf ${lib.getLib pkgs.wasmtime}/lib/libwasmtime.so "$out/${python.sitePackages}/wasmtime/linux-aarch64/_libwasmtime.so"
+    mkdir -p "$out/${python.sitePackages}/wasmtime/${systemDir}"
+    ln -sf ${lib.getLib pkgs.wasmtime}/lib/libwasmtime${libExt} "$out/${python.sitePackages}/wasmtime/${systemDir}/_libwasmtime${libExt}"
   '';
 
   nativeCheckInputs = [