diff --git a/pkgs/development/python-modules/openinference-instrumentation-openai/default.nix b/pkgs/development/python-modules/openinference-instrumentation-openai/default.nix
new file mode 100644
index 000000000000..31a804841153
--- /dev/null
+++ b/pkgs/development/python-modules/openinference-instrumentation-openai/default.nix
@@ -0,0 +1,84 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  hatchling,
+  httpx,
+  nix-update-script,
+  openai,
+  openinference-instrumentation,
+  openinference-semantic-conventions,
+  opentelemetry-api,
+  opentelemetry-instrumentation-httpx,
+  opentelemetry-instrumentation,
+  opentelemetry-semantic-conventions,
+  pytest-asyncio,
+  pytest-vcr,
+  pytestCheckHook,
+  respx,
+  typing-extensions,
+  wrapt,
+}:
+
+buildPythonPackage (finalAttrs: {
+  pname = "openinference-instrumentation-openai";
+  version = "0.1.52";
+  pyproject = true;
+
+  __structuredAttrs = true;
+
+  src = fetchFromGitHub {
+    owner = "Arize-ai";
+    repo = "openinference";
+    tag = "python-openinference-instrumentation-openai-v${finalAttrs.version}";
+    hash = "sha256-wmwqmN/rN521TaXVZfkaRzHPVhANSgKaBVc4rhXgIII=";
+  };
+
+  sourceRoot = "${finalAttrs.src.name}/python/instrumentation/${finalAttrs.pname}";
+
+  build-system = [ hatchling ];
+
+  dependencies = [
+    opentelemetry-api
+    opentelemetry-instrumentation
+    opentelemetry-semantic-conventions
+    openinference-semantic-conventions
+    openinference-instrumentation
+    typing-extensions
+    wrapt
+  ];
+
+  optional-dependencies = {
+    instruments = [ openai ];
+  };
+
+  nativeCheckInputs = [
+    httpx
+    opentelemetry-instrumentation-httpx
+    pytest-asyncio
+    pytest-vcr
+    pytestCheckHook
+    respx
+  ]
+  ++ lib.flatten (builtins.attrValues finalAttrs.passthru.optional-dependencies);
+
+  pythonImportsCheck = [ "openinference.instrumentation.openai" ];
+
+  disabledTests = [
+    # Tests want to connect to OpenAI's API
+    "test_cached_tokens"
+    "test_input_value"
+    "test_openai"
+    "test_tool_calls"
+  ];
+
+  passthru.updateScript = nix-update-script { };
+
+  meta = {
+    description = "OpenInference OpenAI SDK Instrumentation";
+    homepage = "https://github.com/Arize-ai/openinference";
+    changelog = "https://github.com/Arize-ai/openinference/releases/tag/${finalAttrs.src.tag}";
+    license = lib.licenses.asl20;
+    maintainers = with lib.maintainers; [ fab ];
+  };
+})
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 0e51df8e5721..eac8d943c031 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -11842,6 +11842,10 @@ self: super: with self; {
     callPackage ../development/python-modules/openinference-instrumentation-claude-agent-sdk
       { };
 
+  openinference-instrumentation-openai =
+    callPackage ../development/python-modules/openinference-instrumentation-openai
+      { };
+
   openinference-semantic-conventions =
     callPackage ../development/python-modules/openinference-semantic-conventions
       { };