diff --git a/pkgs/by-name/im/imhex/package.nix b/pkgs/by-name/im/imhex/package.nix
index 55283031e79d..2e4ad286a1a0 100644
--- a/pkgs/by-name/im/imhex/package.nix
+++ b/pkgs/by-name/im/imhex/package.nix
@@ -2,7 +2,9 @@
   lib,
   stdenv,
   cmake,
-  llvm,
+  darwin,
+  fetchpatch,
+  llvmPackages_17,
   fetchFromGitHub,
   mbedtls,
   gtk3,
@@ -21,13 +23,24 @@
   nlohmann_json,
   yara,
   rsync,
+  nix-update-script,
   autoPatchelfHook,
+  makeWrapper,
+  overrideSDK,
 }:
 
 let
   version = "1.35.4";
   patterns_version = "1.35.4";
 
+  llvmPackages = llvmPackages_17;
+
+  stdenv' =
+    let
+      baseStdenv = if stdenv.cc.isClang then llvmPackages.stdenv else stdenv;
+    in
+    if stdenv.isDarwin then overrideSDK baseStdenv "11.0" else baseStdenv;
+
   patterns_src = fetchFromGitHub {
     name = "ImHex-Patterns-source-${patterns_version}";
     owner = "WerWolv";
@@ -37,7 +50,7 @@ let
   };
 
 in
-stdenv.mkDerivation rec {
+stdenv'.mkDerivation (finalAttrs: {
   pname = "imhex";
   inherit version;
 
@@ -46,20 +59,39 @@ stdenv.mkDerivation rec {
     fetchSubmodules = true;
     owner = "WerWolv";
     repo = "ImHex";
-    rev = "refs/tags/v${version}";
+    rev = "refs/tags/v${finalAttrs.version}";
     hash = "sha256-6QpmFkSMQpGlEzo7BHZn20c+q8CTDUB4yO87wMU5JT4=";
   };
 
-  nativeBuildInputs = [
-    autoPatchelfHook
-    cmake
-    llvm
-    python3
-    perl
-    pkg-config
-    rsync
+  patches = [
+    # https://github.com/WerWolv/ImHex/pull/1910
+    # during https://github.com/NixOS/nixpkgs/pull/330303 it was discovered that ImHex
+    # would not build on Darwin x86-64
+    # this temporary patch can be removed when the above PR is merged
+    (fetchpatch {
+      url = "https://github.com/WerWolv/ImHex/commit/69624a2661ea44db9fb8b81c3278ef69016ebfcf.patch";
+      hash = "sha256-LcUCl8Rfz6cbhop2StksuViim2bH4ma3/8tGVKFdAgg=";
+    })
   ];
 
+  # Comment out fixup_bundle in PostprocessBundle.cmake as we are not building a standalone application
+  postPatch = lib.optionalString stdenv.isDarwin ''
+    substituteInPlace cmake/modules/PostprocessBundle.cmake \
+      --replace-fail "fixup_bundle" "#fixup_bundle"
+  '';
+
+  nativeBuildInputs =
+    [
+      cmake
+      llvmPackages.llvm
+      python3
+      perl
+      pkg-config
+      rsync
+    ]
+    ++ lib.optionals stdenv.isLinux [ autoPatchelfHook ]
+    ++ lib.optionals stdenv.isDarwin [ makeWrapper ];
+
   buildInputs = [
     capstone
     curl
@@ -73,31 +105,50 @@ stdenv.mkDerivation rec {
     mbedtls
     nlohmann_json
     yara
-  ];
+  ] ++ lib.optionals stdenv.isDarwin [ darwin.apple_sdk_11_0.frameworks.UniformTypeIdentifiers ];
 
   # autoPatchelfHook only searches for *.so and *.so.*, and won't find *.hexpluglib
   # however, we will append to RUNPATH ourselves
-  autoPatchelfIgnoreMissingDeps = [ "*.hexpluglib" ];
-  appendRunpaths = [
+  autoPatchelfIgnoreMissingDeps = lib.optionals stdenv.isLinux [ "*.hexpluglib" ];
+  appendRunpaths = lib.optionals stdenv.isLinux [
     (lib.makeLibraryPath [ libGL ])
     "${placeholder "out"}/lib/imhex/plugins"
   ];
 
   cmakeFlags = [
-    "-DIMHEX_OFFLINE_BUILD=ON"
-    "-DUSE_SYSTEM_CAPSTONE=ON"
-    "-DUSE_SYSTEM_CURL=ON"
-    "-DUSE_SYSTEM_FMT=ON"
-    "-DUSE_SYSTEM_LLVM=ON"
-    "-DUSE_SYSTEM_NLOHMANN_JSON=ON"
-    "-DUSE_SYSTEM_YARA=ON"
+    (lib.cmakeBool "IMHEX_OFFLINE_BUILD" true)
+    (lib.cmakeBool "IMHEX_COMPRESS_DEBUG_INFO" false) # avoids error: cannot compress debug sections (zstd not enabled)
+    (lib.cmakeBool "IMHEX_GENERATE_PACKAGE" stdenv.isDarwin)
+    (lib.cmakeBool "USE_SYSTEM_CAPSTONE" true)
+    (lib.cmakeBool "USE_SYSTEM_CURL" true)
+    (lib.cmakeBool "USE_SYSTEM_FMT" true)
+    (lib.cmakeBool "USE_SYSTEM_LLVM" true)
+    (lib.cmakeBool "USE_SYSTEM_NLOHMANN_JSON" true)
+    (lib.cmakeBool "USE_SYSTEM_YARA" true)
   ];
 
   # rsync is used here so we can not copy the _schema.json files
-  postInstall = ''
-    mkdir -p $out/share/imhex
-    rsync -av --exclude="*_schema.json" ${patterns_src}/{constants,encodings,includes,magic,patterns} $out/share/imhex
-  '';
+  postInstall =
+    if stdenv.isLinux then
+      ''
+        mkdir -p $out/share/imhex
+        rsync -av --exclude="*_schema.json" ${patterns_src}/{constants,encodings,includes,magic,nodes,patterns} $out/share/imhex
+      ''
+    else if stdenv.isDarwin then
+      ''
+        mkdir -p $out/Applications
+        mv $out/imhex.app $out/Applications
+        rsync -av --exclude="*_schema.json" ${patterns_src}/{constants,encodings,includes,magic,nodes,patterns} "$out/Applications/imhex.app/Contents/MacOS"
+        install_name_tool \
+          -change "$out/lib/libimhex.${finalAttrs.version}${stdenv.hostPlatform.extensions.sharedLibrary}" \
+          "@executable_path/../Frameworks/libimhex.${finalAttrs.version}${stdenv.hostPlatform.extensions.sharedLibrary}" \
+          "$out/Applications/imhex.app/Contents/MacOS/imhex"
+        makeWrapper "$out/Applications/imhex.app/Contents/MacOS/imhex" "$out/bin/imhex"
+      ''
+    else
+      throw "Unsupported system";
+
+  passthru.updateScript = nix-update-script { };
 
   meta = with lib; {
     description = "Hex Editor for Reverse Engineers, Programmers and people who value their retinas when working at 3 AM";
@@ -107,6 +158,6 @@ stdenv.mkDerivation rec {
       kashw2
       cafkafk
     ];
-    platforms = platforms.linux;
+    platforms = platforms.linux ++ platforms.darwin;
   };
-}
+})
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index ee7ed2200202..0557a51ad6cf 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -30180,10 +30180,6 @@ with pkgs;
 
   imgp = python3Packages.callPackage ../applications/graphics/imgp { };
 
-  imhex = callPackage ../by-name/im/imhex/package.nix {
-    llvm = llvm_17;
-  };
-
   inframap = callPackage ../applications/networking/cluster/inframap { };
 
   inkcut = libsForQt5.callPackage ../applications/misc/inkcut { };