diff --git a/nixos/doc/manual/from_md/release-notes/rl-2211.section.xml b/nixos/doc/manual/from_md/release-notes/rl-2211.section.xml
index 864b6e47db26..be3adc4d3bed 100644
--- a/nixos/doc/manual/from_md/release-notes/rl-2211.section.xml
+++ b/nixos/doc/manual/from_md/release-notes/rl-2211.section.xml
@@ -267,6 +267,13 @@
           been removed due to lack of upstream maintenance.
         </para>
       </listitem>
+      <listitem>
+        <para>
+          The <literal>meta.mainProgram</literal> attribute of packages
+          in <literal>wineWowPackages</literal> now defaults to
+          <literal>&quot;wine64&quot;</literal>.
+        </para>
+      </listitem>
       <listitem>
         <para>
           (Neo)Vim can not be configured with
diff --git a/nixos/doc/manual/release-notes/rl-2211.section.md b/nixos/doc/manual/release-notes/rl-2211.section.md
index d4059e739322..3f9afe13f1d9 100644
--- a/nixos/doc/manual/release-notes/rl-2211.section.md
+++ b/nixos/doc/manual/release-notes/rl-2211.section.md
@@ -104,6 +104,8 @@ In addition to numerous new and upgraded packages, this release has the followin
   `python3.pkgs.influxgraph` packages, have been removed due to lack of upstream
   maintenance.
 
+- The `meta.mainProgram` attribute of packages in `wineWowPackages` now defaults to `"wine64"`.
+
 - (Neo)Vim can not be configured with `configure.pathogen` anymore to reduce maintainance burden.
 Use `configure.packages` instead.
 
diff --git a/pkgs/applications/emulators/wine/base.nix b/pkgs/applications/emulators/wine/base.nix
index e3875e130a18..a280b9d3e3d6 100644
--- a/pkgs/applications/emulators/wine/base.nix
+++ b/pkgs/applications/emulators/wine/base.nix
@@ -6,7 +6,7 @@
   patches,
   vkd3dArches,
   moltenvk,
-  buildScript ? null, configureFlags ? []
+  buildScript ? null, configureFlags ? [], mainProgram ? "wine"
 }:
 
 with import ./util.nix { inherit lib; };
@@ -198,6 +198,6 @@ stdenv.mkDerivation ((lib.optionalAttrs (buildScript != null) {
     description = if supportFlags.waylandSupport then "An Open Source implementation of the Windows API on top of OpenGL and Unix (with experimental Wayland support)" else "An Open Source implementation of the Windows API on top of X, OpenGL, and Unix";
     platforms = if supportFlags.waylandSupport then (lib.remove "x86_64-darwin" prevPlatforms) else prevPlatforms;
     maintainers = with lib.maintainers; [ avnik raskin bendlas jmc-figueira ];
-    mainProgram = "wine";
+    inherit mainProgram;
   };
 })
diff --git a/pkgs/applications/emulators/wine/packages.nix b/pkgs/applications/emulators/wine/packages.nix
index c119feb783d3..3b5aa19658ce 100644
--- a/pkgs/applications/emulators/wine/packages.nix
+++ b/pkgs/applications/emulators/wine/packages.nix
@@ -28,6 +28,7 @@ in with src; {
     monos =  [ mono ];
     configureFlags = [ "--enable-win64" ];
     platforms = [ "x86_64-linux" "x86_64-darwin" ];
+    mainProgram = "wine64";
   };
   wineWow = callPackage ./base.nix {
     pname = "wine-wow";
@@ -40,5 +41,6 @@ in with src; {
     monos =  [ mono ];
     buildScript = ./builder-wow.sh;
     platforms = [ "x86_64-linux" ];
+    mainProgram = "wine64";
   };
 }