diff --git a/pkgs/development/python-modules/debugpy/default.nix b/pkgs/development/python-modules/debugpy/default.nix
index c45d6621398f..4035cc52328e 100644
--- a/pkgs/development/python-modules/debugpy/default.nix
+++ b/pkgs/development/python-modules/debugpy/default.nix
@@ -13,6 +13,7 @@
 , pytest-xdist
 , pytestCheckHook
 , requests
+, llvmPackages
 }:
 
 buildPythonPackage rec {
@@ -30,12 +31,6 @@ buildPythonPackage rec {
   };
 
   patches = [
-    # Hard code GDB path (used to attach to process)
-    (substituteAll {
-      src = ./hardcode-gdb.patch;
-      inherit gdb;
-    })
-
     # Use nixpkgs version instead of versioneer
     (substituteAll {
       src = ./hardcode-version.patch;
@@ -51,6 +46,18 @@ buildPythonPackage rec {
     # To avoid this issue, debugpy should be installed using python.withPackages:
     # python.withPackages (ps: with ps; [ debugpy ])
     ./fix-test-pythonpath.patch
+  ] ++ lib.optionals stdenv.isLinux [
+    # Hard code GDB path (used to attach to process)
+    (substituteAll {
+      src = ./hardcode-gdb.patch;
+      inherit gdb;
+    })
+  ] ++ lib.optionals stdenv.isDarwin [
+    # Hard code LLDB path (used to attach to process)
+    (substituteAll {
+      src = ./hardcode-lldb.patch;
+      inherit (llvmPackages) lldb;
+    })
   ];
 
   # Remove pre-compiled "attach" libraries and recompile for host platform
diff --git a/pkgs/development/python-modules/debugpy/hardcode-lldb.patch b/pkgs/development/python-modules/debugpy/hardcode-lldb.patch
new file mode 100644
index 000000000000..43ededa083cf
--- /dev/null
+++ b/pkgs/development/python-modules/debugpy/hardcode-lldb.patch
@@ -0,0 +1,13 @@
+diff --git a/src/debugpy/_vendored/pydevd/pydevd_attach_to_process/add_code_to_python_process.py b/src/debugpy/_vendored/pydevd/pydevd_attach_to_process/add_code_to_python_process.py
+index ed43e370..b28ab453 100644
+--- a/src/debugpy/_vendored/pydevd/pydevd_attach_to_process/add_code_to_python_process.py
++++ b/src/debugpy/_vendored/pydevd/pydevd_attach_to_process/add_code_to_python_process.py
+@@ -494,7 +494,7 @@ def run_python_code_mac(pid, python_code, connect_debugger_tracing=False, show_d
+     is_debug = 0
+     # Note that the space in the beginning of each line in the multi-line is important!
+     cmd = [
+-        'lldb',
++        '@lldb@/bin/lldb',
+         '--no-lldbinit',  # Do not automatically parse any '.lldbinit' files.
+         # '--attach-pid',
+         # str(pid),