diff --git a/pkgs/development/python-modules/scikit-hep-testdata/default.nix b/pkgs/development/python-modules/scikit-hep-testdata/default.nix
new file mode 100644
index 000000000000..281564601102
--- /dev/null
+++ b/pkgs/development/python-modules/scikit-hep-testdata/default.nix
@@ -0,0 +1,47 @@
+{ lib
+, fetchFromGitHub
+, pythonAtLeast
+, buildPythonPackage
+, importlib-resources
+, pyyaml
+, requests
+, pytestCheckHook
+, setuptools-scm
+}:
+
+buildPythonPackage rec {
+  pname = "scikit-hep-testdata";
+  version = "0.4.3";
+  format = "pyproject";
+
+  # fetch from github as we want the data files
+  # https://github.com/scikit-hep/scikit-hep-testdata/issues/60
+  src = fetchFromGitHub {
+    owner = "scikit-hep";
+    repo = pname;
+    rev = "v${version}";
+    sha256 = "sha256-3uy2uZb0Y9nOHlXtsDd9LGALvTXl1ZQ6P3m2dQ2ceHo=";
+  };
+
+  nativeBuildInputs = [
+    setuptools-scm
+  ];
+  propagatedBuildInputs = [
+    pyyaml
+    requests
+  ] ++ lib.optional (!pythonAtLeast "3.9") importlib-resources;
+
+  SETUPTOOLS_SCM_PRETEND_VERSION = version;
+
+  SKHEP_DATA = 1; # install the actual root files
+
+  doCheck = false; # tests require networking
+  pythonImportsCheck = [ "skhep_testdata" ];
+
+  meta = with lib; {
+    homepage = "https://github.com/scikit-hep/scikit-hep-testdata";
+    description = "A common package to provide example files (e.g., ROOT) for testing and developing packages against";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ veprbl ];
+  };
+}
diff --git a/pkgs/development/python-modules/uproot/default.nix b/pkgs/development/python-modules/uproot/default.nix
new file mode 100644
index 000000000000..8a687534005e
--- /dev/null
+++ b/pkgs/development/python-modules/uproot/default.nix
@@ -0,0 +1,61 @@
+{ lib
+, fetchFromGitHub
+, buildPythonPackage
+, awkward
+, numpy
+, lz4
+, xxhash
+, zstandard
+, pytestCheckHook
+, scikit-hep-testdata
+}:
+
+buildPythonPackage rec {
+  pname = "uproot";
+  version = "4.0.8";
+
+  # fetch from github for tests
+  src = fetchFromGitHub {
+    owner = "scikit-hep";
+    repo = "uproot4";
+    rev = version;
+    sha256 = "sha256-E9BRgyMz+3Xl8Q1zsnVtvW44FXTqs29U1oK4te0myq4=";
+  };
+
+  propagatedBuildInputs = [
+    awkward
+    numpy
+    lz4
+    xxhash
+    zstandard
+  ];
+
+  checkInputs = [
+    pytestCheckHook
+    scikit-hep-testdata
+  ];
+  preCheck = ''
+    export HOME="$(mktemp -d)"
+  '';
+  disabledTests = [
+    # tests that try to download files
+    "test_http"
+    "test_no_multipart"
+    "test_fallback"
+    "test_pickle_roundtrip_http"
+  ];
+  disabledTestPaths = [
+    # tests that try to download files
+    "tests/test_0066-fix-http-fallback-freeze.py"
+    "tests/test_0088-read-with-http.py"
+    "tests/test_0220-contiguous-byte-ranges-in-http.py"
+  ];
+  pythonImportsCheck = [ "uproot" ];
+
+  meta = with lib; {
+    homepage = "https://github.com/scikit-hep/uproot4";
+    description = "ROOT I/O in pure Python and Numpy";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ veprbl ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b92607502d92..50d02dbfdffe 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -7471,6 +7471,8 @@ in {
 
   scikit-fuzzy = callPackage ../development/python-modules/scikit-fuzzy { };
 
+  scikit-hep-testdata = callPackage ../development/python-modules/scikit-hep-testdata { };
+
   scikitimage = callPackage ../development/python-modules/scikit-image { };
 
   scikit-learn = callPackage ../development/python-modules/scikit-learn {
@@ -8610,6 +8612,8 @@ in {
 
   upnpy = callPackage ../development/python-modules/upnpy { };
 
+  uproot = callPackage ../development/python-modules/uproot { };
+
   uproot3 = callPackage ../development/python-modules/uproot3 { };
 
   uproot3-methods = callPackage ../development/python-modules/uproot3-methods { };