diff --git a/pkgs/development/python-modules/macropy/default.nix b/pkgs/development/python-modules/macropy/default.nix
deleted file mode 100644
index 6a9de5a4f57c..000000000000
--- a/pkgs/development/python-modules/macropy/default.nix
+++ /dev/null
@@ -1,43 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  python,
-  isPy27,
-  pythonAtLeast,
-  pinqSupport ? false,
-  sqlalchemy,
-  pyxlSupport ? false,
-  pyxl3,
-}:
-
-buildPythonPackage rec {
-  # https://github.com/lihaoyi/macropy/issues/94
-  version = "1.1.0b2";
-  format = "setuptools";
-  pname = "macropy";
-  disabled = isPy27;
-
-  src = fetchFromGitHub {
-    owner = "lihaoyi";
-    repo = "macropy";
-    rev = "v${version}";
-    sha256 = "1bd2fzpa30ddva3f8lw2sbixxf069idwib8srd64s5v46ricm2cf";
-  };
-
-  # js_snippets extra only works with python2
-  propagatedBuildInputs =
-    [ ] ++ lib.optional pinqSupport sqlalchemy ++ lib.optional pyxlSupport pyxl3;
-
-  checkPhase = ''
-    ${python.interpreter} run_tests.py
-  '';
-
-  meta = with lib; {
-    homepage = "https://github.com/lihaoyi/macropy";
-    description = "Macros in Python: quasiquotes, case classes, LINQ and more";
-    license = licenses.mit;
-    maintainers = [ ];
-    broken = pythonAtLeast "3.8"; # see https://github.com/lihaoyi/macropy/issues/103
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index f17434b17512..3c9d658bb22f 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -427,6 +427,7 @@ mapAliases ({
   markdownsuperscript = throw "markdownsuperscript is unmaintained, use pymdown-extensions"; # added 2023-06-10
   mask-rcnn = throw "mask-rcnn has been removed as it is unmaintained and its dependency imgaug no longer builds"; # added 2023-07-10
   mac_alias = mac-alias; # added 2024-01-07
+  macropy = throw "macropy has been removed as it was broken since 2020"; # added 2025-10-04
   MDP = mdp; # added 2023-02-19
   mdp = throw "mdp has been removed as it is unmaintained and broken"; # added 2024-11-23
   MechanicalSoup = mechanicalsoup; # added 2021-06-01
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f0f0db0aea59..9532692533bb 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8900,8 +8900,6 @@ self: super: with self; {
 
   macholib = callPackage ../development/python-modules/macholib { };
 
-  macropy = callPackage ../development/python-modules/macropy { };
-
   maec = callPackage ../development/python-modules/maec { };
 
   maestral = callPackage ../development/python-modules/maestral { };