diff --git a/pkgs/development/python-modules/flaky/default.nix b/pkgs/development/python-modules/flaky/default.nix
index 65efea30db6c..43b3288f94b9 100644
--- a/pkgs/development/python-modules/flaky/default.nix
+++ b/pkgs/development/python-modules/flaky/default.nix
@@ -2,27 +2,29 @@
 , buildPythonPackage
 , fetchPypi
 , mock
-, nose
 , pytest
 }:
 
 buildPythonPackage rec {
   pname = "flaky";
   version = "3.7.0";
+  format = "setuptools";
 
   src = fetchPypi {
     inherit pname version;
-    sha256 = "3ad100780721a1911f57a165809b7ea265a7863305acb66708220820caf8aa0d";
+    hash = "sha256-OtEAeAchoZEfV6FlgJt+omWnhjMFrLZnCCIIIMr4qg0=";
   };
 
-  nativeCheckInputs = [ mock nose pytest ];
+  nativeCheckInputs = [
+    mock
+    pytest
+  ];
 
   checkPhase = ''
     # based on tox.ini
     pytest -k 'example and not options' --doctest-modules test/test_pytest/
     pytest -k 'example and not options' test/test_pytest/
     pytest -p no:flaky test/test_pytest/test_flaky_pytest_plugin.py
-    nosetests --with-flaky --force-flaky --max-runs 2 test/test_nose/test_nose_options_example.py
     pytest --force-flaky --max-runs 2  test/test_pytest/test_pytest_options_example.py
   '';
 
diff --git a/pkgs/development/python-modules/hypothesis/default.nix b/pkgs/development/python-modules/hypothesis/default.nix
index b3f93e03f283..bfa2ca0dc87e 100644
--- a/pkgs/development/python-modules/hypothesis/default.nix
+++ b/pkgs/development/python-modules/hypothesis/default.nix
@@ -1,5 +1,6 @@
 { lib
 , buildPythonPackage
+, isPyPy
 , fetchFromGitHub
 , attrs
 , exceptiongroup
@@ -13,6 +14,7 @@
 , sphinx-rtd-theme
 , sphinx-hoverxref
 , sphinx-codeautolink
+, tzdata
 # Used to break internal dependency loop.
 , enableDocumentation ? true
 }:
@@ -65,6 +67,8 @@ buildPythonPackage rec {
     pexpect
     pytest-xdist
     pytestCheckHook
+  ] ++ lib.optionals (isPyPy) [
+    tzdata
   ];
 
   inherit doCheck;
diff --git a/pkgs/development/python-modules/nose/default.nix b/pkgs/development/python-modules/nose/default.nix
index c4a52a0e114b..bb6f6decc1a5 100644
--- a/pkgs/development/python-modules/nose/default.nix
+++ b/pkgs/development/python-modules/nose/default.nix
@@ -26,7 +26,7 @@ buildPythonPackage rec {
       --replace "from setuptools.command.build_py import Mixin2to3" "from distutils.util import Mixin2to3"
   '';
 
-  preBuild = lib.optionalString (isPy3k && (!isPyPy)) ''
+  preBuild = lib.optionalString (isPy3k) ''
     ${python.pythonForBuild}/bin/2to3 -wn nose functional_tests unit_tests
   '';
 
@@ -41,6 +41,7 @@ buildPythonPackage rec {
   '';
 
   meta = with lib; {
+    broken = isPyPy; # missing 2to3 conversion utility
     description = "A unittest-based testing framework for python that makes writing and running tests easier";
     homepage = "https://nose.readthedocs.io/";
     license = licenses.lgpl3;
diff --git a/pkgs/development/python-modules/virtualenv/default.nix b/pkgs/development/python-modules/virtualenv/default.nix
index 30e3fc43d63f..28100b8c55e7 100644
--- a/pkgs/development/python-modules/virtualenv/default.nix
+++ b/pkgs/development/python-modules/virtualenv/default.nix
@@ -1,8 +1,8 @@
 { lib
-, stdenv
 , buildPythonPackage
 , pythonOlder
 , isPy27
+, isPyPy
 , cython
 , distlib
 , fetchPypi
@@ -12,7 +12,6 @@
 , hatchling
 , importlib-metadata
 , importlib-resources
-, pathlib2
 , platformdirs
 , pytest-freezegun
 , pytest-mock
@@ -76,6 +75,13 @@ buildPythonPackage rec {
     "test_seed_link_via_app_data"
     # Permission Error
     "test_bad_exe_py_info_no_raise"
+  ] ++ lib.optionals (isPyPy) [
+    # encoding problems
+    "test_bash"
+    # permission error
+    "test_can_build_c_extensions"
+    # fails to detect pypy version
+    "test_discover_ok"
   ];
 
   pythonImportsCheck = [
diff --git a/pkgs/development/python-modules/yapf/default.nix b/pkgs/development/python-modules/yapf/default.nix
index 80b84b73ff97..f5cba78a2026 100644
--- a/pkgs/development/python-modules/yapf/default.nix
+++ b/pkgs/development/python-modules/yapf/default.nix
@@ -1,6 +1,7 @@
 { lib
 , buildPythonPackage
 , fetchPypi
+, isPyPy
 , nose
 }:
 
@@ -13,6 +14,9 @@ buildPythonPackage rec {
     hash = "sha256-o/UIXTfvfj4ATEup+bPkDFT/GQHNER8FFFrjE6fGfRs=";
   };
 
+  # nose is unavailable on pypy
+  doCheck = !isPyPy;
+
   nativeCheckInputs = [
     nose
   ];