diff --git a/pkgs/development/libraries/libquotient/default.nix b/pkgs/development/libraries/libquotient/default.nix
index eea7eeb88fc7..0f75c8d1f4e5 100644
--- a/pkgs/development/libraries/libquotient/default.nix
+++ b/pkgs/development/libraries/libquotient/default.nix
@@ -20,6 +20,13 @@ mkDerivation rec {
     "-DQuotient_ENABLE_E2EE=OFF"
   ];
 
+  # https://github.com/quotient-im/libQuotient/issues/551
+  postPatch = ''
+    substituteInPlace Quotient.pc.in \
+      --replace '$'{prefix}/@CMAKE_INSTALL_LIBDIR@ @CMAKE_INSTALL_FULL_LIBDIR@ \
+      --replace '$'{prefix}/@CMAKE_INSTALL_INCLUDEDIR@ @CMAKE_INSTALL_FULL_INCLUDEDIR@
+  '';
+
   meta = with lib; {
     description = "A Qt5 library to write cross-platform clients for Matrix";
     homepage = "https://matrix.org/docs/projects/sdk/quotient";