diff --git a/pkgs/development/python-modules/pycryptodomex/default.nix b/pkgs/development/python-modules/pycryptodomex/default.nix
new file mode 100644
index 000000000000..1d1ac67732a3
--- /dev/null
+++ b/pkgs/development/python-modules/pycryptodomex/default.nix
@@ -0,0 +1,18 @@
+{ lib, buildPythonPackage, fetchPypi }:
+
+buildPythonPackage rec {
+  pname = "pycryptodomex";
+  name = "${pname}-${version}";
+  version = "3.4.5";
+
+  meta = {
+    description = "A self-contained cryptographic library for Python";
+    homepage = https://www.pycryptodome.org;
+    license = lib.licenses.bsd2;
+  };
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "1n5w5ls5syapmb39kavqgz2sa9pinzx4c9dvwa2147gj0hkh87wj";
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 15ceba80199e..c663ca4f957e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -225,6 +225,8 @@ in {
 
   pycryptodome = callPackage ../development/python-modules/pycryptodome { };
 
+  pycryptodomex = callPackage ../development/python-modules/pycryptodomex { };
+
   PyChromecast = callPackage ../development/python-modules/pychromecast {
     protobuf = self.protobuf3_2;
   };