diff --git a/pkgs/applications/science/chemistry/d-seams/default.nix b/pkgs/applications/science/chemistry/d-seams/default.nix
index 74260bacabcc..dc41019d364b 100644
--- a/pkgs/applications/science/chemistry/d-seams/default.nix
+++ b/pkgs/applications/science/chemistry/d-seams/default.nix
@@ -1,4 +1,4 @@
-{ clangStdenv, fetchFromGitHub, catch2, rang, fmt, libyamlcpp, cmake
+{ clangStdenv, fetchFromGitHub, fetchpatch, catch2, rang, fmt, libyamlcpp, cmake
 , eigen, lua, luaPackages, liblapack, blas, lib, boost, gsl }:
 
 clangStdenv.mkDerivation rec {
@@ -12,6 +12,13 @@ clangStdenv.mkDerivation rec {
     sha256 = "03zhhl9vhi3rhc3qz1g3zb89jksgpdlrk15fcr8xcz8pkj6r5b1i";
   };
 
+  patches = [
+    (fetchpatch {
+      name = "use_newer_cxxopts_which_builds_with_clang11.patch";
+      url = "https://github.com/d-SEAMS/seams-core/commit/f6156057e43d0aa1a0df9de67d8859da9c30302d.patch";
+      hash = "sha256-PLbT1lqdw+69lIHH96MPcGRjfIeZyb88vc875QLYyqw=";
+    })
+  ];
   nativeBuildInputs = [ cmake lua luaPackages.luafilesystem ];
   buildInputs = [ fmt rang libyamlcpp eigen catch2 boost gsl liblapack blas ];