diff --git a/pkgs/applications/networking/mailreaders/ayatana-webmail/default.nix b/pkgs/applications/networking/mailreaders/ayatana-webmail/default.nix
new file mode 100644
index 000000000000..14be9ab4f3d6
--- /dev/null
+++ b/pkgs/applications/networking/mailreaders/ayatana-webmail/default.nix
@@ -0,0 +1,90 @@
+{ lib
+, fetchFromGitHub
+, gettext
+, gtk3
+, python3Packages
+, gdk-pixbuf
+, libnotify
+, glib
+, gobject-introspection
+, wrapGAppsHook
+# BTW libappindicator is also supported, but upstream recommends their
+# implementation, see:
+# https://github.com/AyatanaIndicators/ayatana-webmail/issues/24#issuecomment-1050352862
+, libayatana-appindicator
+, gsettings-desktop-schemas
+, libcanberra-gtk3
+}:
+
+python3Packages.buildPythonApplication rec {
+  pname = "ayatana-webmail";
+  version = "22.12.15";
+
+  src = fetchFromGitHub {
+    owner = "AyatanaIndicators";
+    repo = "ayatana-webmail";
+    rev = version;
+    hash = "sha256-K2jqCWrY1i1wYdZVpjN/3TcVyWariOQQ4slZf6sEPRU=";
+  };
+  postConfigure = ''
+    # Fix fhs paths
+    substituteInPlace \
+      ayatanawebmail/accounts.py \
+      ayatanawebmail/actions.py \
+      ayatanawebmail/dialog.py \
+      --replace /usr/share $out/share
+  '';
+
+  buildInputs = [
+    gtk3
+    gdk-pixbuf
+    glib
+    libnotify
+    gettext
+    libayatana-appindicator
+    gsettings-desktop-schemas
+  ];
+
+  nativeBuildInputs = [
+    gobject-introspection
+    wrapGAppsHook
+    glib # For compiling gsettings-schemas
+  ];
+
+  propagatedBuildInputs = with python3Packages; [
+    urllib3
+    babel
+    psutil
+    secretstorage
+    polib
+    pygobject3
+    dbus-python
+  ];
+
+  # No tests, and they cause a failure
+  doCheck = false;
+
+  postInstall = ''
+    # Fix fhs paths
+    mv $out/${python3Packages.python.sitePackages}/etc $out
+    mv $out/${python3Packages.python.sitePackages}/usr/{bin,share} $out/
+    rmdir $out/${python3Packages.python.sitePackages}/usr
+    # Compile gsettings desktop schemas
+    glib-compile-schemas $out/share/glib-2.0/schemas
+  '';
+
+  # See https://nixos.org/nixpkgs/manual/#ssec-gnome-common-issues-double-wrapped
+  dontWrapGApps = true;
+  preFixup = ''
+    makeWrapperArgs+=("''${gappsWrapperArgs[@]}")
+    makeWrapperArgs+=(--prefix PATH : ${lib.makeBinPath [ libcanberra-gtk3 ]})
+  '';
+
+  meta = with lib; {
+    description = "Webmail notifications and actions for any desktop";
+    homepage = "https://github.com/AyatanaIndicators/ayatana-webmail";
+    license = licenses.gpl3Plus;
+    platforms = platforms.linux;
+    maintainers = with maintainers; [ doronbehar ];
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index d9e4b88db37f..d0d62614a22e 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -20036,6 +20036,8 @@ with pkgs;
 
   ayatana-ido = callPackage ../development/libraries/ayatana-ido { };
 
+  ayatana-webmail = callPackage ../applications/networking/mailreaders/ayatana-webmail { };
+
   babl = callPackage ../development/libraries/babl { };
 
   backward-cpp = callPackage ../development/libraries/backward-cpp { };