diff --git a/pkgs/development/libraries/opencolorio/default.nix b/pkgs/development/libraries/opencolorio/default.nix
index d9de24b7fa04..522c8cfa4a13 100644
--- a/pkgs/development/libraries/opencolorio/default.nix
+++ b/pkgs/development/libraries/opencolorio/default.nix
@@ -1,4 +1,16 @@
-{ stdenv, lib, fetchFromGitHub, cmake, expat, libyamlcpp, ilmbase, pystring, lcms2, python3Packages }:
+{
+  stdenv, lib, fetchFromGitHub,
+  cmake, expat, libyamlcpp, ilmbase, pystring, # Base dependencies
+
+  glew, freeglut, # Only required on Linux
+  Carbon, GLUT, Cocoa, # Only required on Darwin
+
+  pythonBindings ? true, # Python bindings
+  python3Packages,
+
+  buildApps ? true, # Utility applications
+  lcms2, openimageio2, openexr,
+}:
 
 with lib;
 
@@ -14,9 +26,18 @@ stdenv.mkDerivation rec {
   };
 
   nativeBuildInputs = [ cmake ];
-  buildInputs = [ expat libyamlcpp ilmbase pystring lcms2 python3Packages.pybind11 ];
+  buildInputs = [ expat libyamlcpp ilmbase pystring ]
+    ++ lib.optionals stdenv.hostPlatform.isLinux [ glew freeglut ]
+    ++ lib.optionals stdenv.hostPlatform.isDarwin [ Carbon GLUT Cocoa ]
+    ++ lib.optionals pythonBindings [ python3Packages.python python3Packages.pybind11 ]
+    ++ lib.optionals buildApps [ lcms2 openimageio2 openexr ];
 
-  cmakeFlags = [ "-DOCIO_INSTALL_EXT_PACKAGES=NONE" ];
+    cmakeFlags = [ "-DOCIO_INSTALL_EXT_PACKAGES=NONE" ]
+    ++ lib.optional (!pythonBindings) "-DOCIO_BUILD_PYTHON=OFF"
+    ++ lib.optional (!buildApps) "-DOCIO_BUILD_APPS=OFF";
+
+  # TODO Investigate this: Python and GPU tests fail to load libOpenColorIO.so.2.0
+  # doCheck = true;
 
   meta = with lib; {
     homepage = "https://opencolorio.org";
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 42306cf5b27b..2877c8da84d2 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -17514,7 +17514,9 @@ in
   openldap = callPackage ../development/libraries/openldap { };
 
   opencolorio1 = callPackage ../development/libraries/opencolorio/1.x.nix { };
-  opencolorio2 = callPackage ../development/libraries/opencolorio { };
+  opencolorio2 = callPackage ../development/libraries/opencolorio {
+    inherit (darwin.apple_sdk.frameworks) Carbon GLUT Cocoa;
+  };
   opencolorio = opencolorio1;
 
   opendmarc = callPackage ../development/libraries/opendmarc { };