diff --git a/pkgs/development/python-modules/pyuv/default.nix b/pkgs/development/python-modules/pyuv/default.nix
index 2d276c6dccab..2f1870dd1c85 100644
--- a/pkgs/development/python-modules/pyuv/default.nix
+++ b/pkgs/development/python-modules/pyuv/default.nix
@@ -1,5 +1,6 @@
 { lib
 , buildPythonPackage
+, pythonAtLeast
 , fetchFromGitHub
 , libuv
 }:
@@ -7,6 +8,7 @@
 buildPythonPackage rec {
   pname = "pyuv";
   version = "1.4.0";
+  disabled = pythonAtLeast "3.10"; # https://github.com/saghul/pyuv/issues/273
 
   src = fetchFromGitHub {
     owner = "saghul";