diff --git a/pkgs/development/python-modules/ipython/default.nix b/pkgs/development/python-modules/ipython/default.nix
index cee9868cfacb..c1c0b049dc8c 100644
--- a/pkgs/development/python-modules/ipython/default.nix
+++ b/pkgs/development/python-modules/ipython/default.nix
@@ -76,6 +76,11 @@ buildPythonPackage rec {
     testpath
   ];
 
+  disabledTests = lib.optionals (stdenv.isDarwin) [
+    # FileNotFoundError: [Errno 2] No such file or directory: 'pbpaste'
+    "test_clipboard_get"
+  ];
+
   meta = with lib; {
     description = "IPython: Productive Interactive Computing";
     homepage = "http://ipython.org/";