diff --git a/pkgs/development/libraries/webp-pixbuf-loader/default.nix b/pkgs/development/libraries/webp-pixbuf-loader/default.nix
index b3f4e4d48390..78496c0e919e 100644
--- a/pkgs/development/libraries/webp-pixbuf-loader/default.nix
+++ b/pkgs/development/libraries/webp-pixbuf-loader/default.nix
@@ -52,6 +52,9 @@ stdenv.mkDerivation rec {
     GDK_PIXBUF_MODULEDIR="$out/${moduleDir}" \
     gdk-pixbuf-query-loaders --update-cache
 
+    # gdk-pixbuf disables the thumbnailer in cross-builds (https://gitlab.gnome.org/GNOME/gdk-pixbuf/-/commit/fc37708313a5fc52083cf10c9326f3509d67701f)
+    # and therefore makeWrapper will fail because 'gdk-pixbuf-thumbnailer' the executable does not exist.
+  '' + lib.optionalString (stdenv.hostPlatform == stdenv.buildPlatform) ''
     # It assumes gdk-pixbuf-thumbnailer can find the webp loader in the loaders.cache referenced by environment variable, breaking containment.
     # So we replace it with a wrapped executable.
     mkdir -p "$out/bin"