diff --git a/pkgs/development/python-modules/snakemake-storage-plugin-xrootd/default.nix b/pkgs/development/python-modules/snakemake-storage-plugin-xrootd/default.nix
index fc67fd23a9ad..802082fd6bfa 100644
--- a/pkgs/development/python-modules/snakemake-storage-plugin-xrootd/default.nix
+++ b/pkgs/development/python-modules/snakemake-storage-plugin-xrootd/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   pkgs,
   buildPythonPackage,
   fetchFromGitHub,
@@ -51,7 +52,9 @@ buildPythonPackage (finalAttrs: {
     xrootd
   ];
 
-  pythonImportsCheck = [ "snakemake_storage_plugin_xrootd" ];
+  # When doCheck is disabled, nnativeCheckInputs are not available and the package fails to import:
+  #   ModuleNotFoundError: No module named 'snakemake'
+  pythonImportsCheck = lib.optionals finalAttrs.doCheck [ "snakemake_storage_plugin_xrootd" ];
 
   nativeCheckInputs = [
     pytestCheckHook
@@ -60,6 +63,16 @@ buildPythonPackage (finalAttrs: {
 
   enabledTestPaths = [ "tests/tests.py" ];
 
+  # Tests fail on darwin even with:
+  # - __darwinAllowLocalNetworking = true;
+  # - sandbox = false
+  # - writableTmpDirAsHomeHook
+  #
+  # Failed: XRootD server terminated unexpectedly.
+  # 260604 22:16:56 259 XrdConfig: Unable to set permission for admin path /tmp/.xrd/; operation not permitted
+  # ------ xrootd anon@91-224-148-58.tetaneutral.net:32293 initialization failed.
+  doCheck = !stdenv.hostPlatform.isDarwin;
+
   meta = {
     description = "Snakemake storage plugin for handling input and output via XRootD";
     homepage = "https://github.com/snakemake/snakemake-storage-plugin-xrootd";