diff --git a/pkgs/development/python-modules/pyannotate/default.nix b/pkgs/development/python-modules/pyannotate/default.nix
index 6c81a3f081b8..d77b60248132 100644
--- a/pkgs/development/python-modules/pyannotate/default.nix
+++ b/pkgs/development/python-modules/pyannotate/default.nix
@@ -4,14 +4,16 @@
   fetchPypi,
   mypy-extensions,
   pytestCheckHook,
+  pythonAtLeast,
   pythonOlder,
+  setuptools,
   six,
 }:
 
 buildPythonPackage rec {
   pname = "pyannotate";
   version = "1.2.0";
-  format = "setuptools";
+  pyproject = true;
 
   disabled = pythonOlder "3.7";
 
@@ -20,7 +22,9 @@ buildPythonPackage rec {
     hash = "sha256-BO1YBLqzgVPVmB/JLYPc9qIog0U3aFYfBX53flwFdZk=";
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     six
     mypy-extensions
   ];
@@ -32,11 +36,20 @@ buildPythonPackage rec {
     "pyannotate_tools"
   ];
 
+  disabledTestPaths =
+    [
+      "pyannotate_runtime/tests/test_collect_types.py"
+    ]
+    ++ lib.optionals (pythonAtLeast "3.11") [
+      # Tests are using lib2to3
+      "pyannotate_tools/fixes/tests/test_annotate*.py"
+    ];
+
   meta = with lib; {
     description = "Auto-generate PEP-484 annotations";
-    mainProgram = "pyannotate";
     homepage = "https://github.com/dropbox/pyannotate";
     license = licenses.mit;
     maintainers = [ ];
+    mainProgram = "pyannotate";
   };
 }