diff --git a/pkgs/development/python-modules/pycryptodome/default.nix b/pkgs/development/python-modules/pycryptodome/default.nix
index 025faf27da32..4170ded2f6a1 100644
--- a/pkgs/development/python-modules/pycryptodome/default.nix
+++ b/pkgs/development/python-modules/pycryptodome/default.nix
@@ -4,6 +4,7 @@
   callPackage,
   fetchFromGitHub,
   gmp,
+  setuptools,
 }:
 
 let
@@ -11,21 +12,23 @@ let
 in
 buildPythonPackage rec {
   pname = "pycryptodome";
-  version = "3.21.0";
-  format = "setuptools";
+  version = "3.22.0";
+  pyproject = true;
 
   src = fetchFromGitHub {
     owner = "Legrandin";
     repo = "pycryptodome";
     tag = "v${version}";
-    hash = "sha256-4GnjHDYJY1W3n6lUtGfk5KDMQfe5NoKbYn94TTXYCDY=";
+    hash = "sha256-jc/o2HtpJ908NiBh9Ii5dQkQ9USHRPjRPtBHC+YqCmU=";
   };
 
   postPatch = ''
     substituteInPlace lib/Crypto/Math/_IntegerGMP.py \
-      --replace 'load_lib("gmp"' 'load_lib("${gmp}/lib/libgmp.so.10"'
+      --replace-fail 'load_lib("gmp"' 'load_lib("${gmp}/lib/libgmp.so.10"'
   '';
 
+  build-system = [ setuptools ];
+
   nativeCheckInputs = [ test-vectors ];
 
   pythonImportsCheck = [ "Crypto" ];