diff --git a/pkgs/development/python-modules/granian/default.nix b/pkgs/development/python-modules/granian/default.nix
index 739d4cbab3f2..8a75a70eaa59 100644
--- a/pkgs/development/python-modules/granian/default.nix
+++ b/pkgs/development/python-modules/granian/default.nix
@@ -13,6 +13,7 @@
   pytest-asyncio,
   websockets,
   httpx,
+  rust-jemalloc-sys,
   sniffio,
   nix-update-script,
 }:
@@ -39,6 +40,21 @@ buildPythonPackage rec {
     maturinBuildHook
   ];
 
+  buildInputs = [
+    # fix "Unsupported system page size" on aarch64-linux with 16k pages
+    # https://github.com/NixOS/nixpkgs/issues/410572
+    (rust-jemalloc-sys.overrideAttrs (
+      { configureFlags, ... }:
+      {
+        configureFlags = configureFlags ++ [
+          # otherwise import check fails with:
+          # ImportError: {{storeDir}}/lib/libjemalloc.so.2: cannot allocate memory in static TLS block
+          "--disable-initial-exec-tls"
+        ];
+      }
+    ))
+  ];
+
   dependencies = [
     click
   ];