diff --git a/pkgs/development/python-modules/highdicom/default.nix b/pkgs/development/python-modules/highdicom/default.nix
index bc0d93d35fd1..08422adc1f49 100644
--- a/pkgs/development/python-modules/highdicom/default.nix
+++ b/pkgs/development/python-modules/highdicom/default.nix
@@ -2,6 +2,7 @@
   lib,
   buildPythonPackage,
   fetchFromGitHub,
+  fetchpatch2,
   pytestCheckHook,
   numpy,
   pillow,
@@ -26,6 +27,14 @@ buildPythonPackage rec {
     hash = "sha256-Tfy7u5MVapRE24CZLFzTnYChnH9JJ9V7FuUhDoktBFc=";
   };
 
+  patches = [
+    # Fix time-of-day-dependent failure in series_time validation.
+    (fetchpatch2 {
+      url = "https://github.com/ImagingDataCommons/highdicom/commit/e9e3f2514a74b0d4be736cff222c934ef66d67ff.patch";
+      hash = "sha256-48dJAimxXYG0FQouquY5TLXi+3HarS8yx9HoLXiFymM=";
+    })
+  ];
+
   build-system = [
     setuptools
   ];