diff --git a/pkgs/development/python-modules/pyquil/default.nix b/pkgs/development/python-modules/pyquil/default.nix
index ce438b6f3c74..0c380bcddc69 100644
--- a/pkgs/development/python-modules/pyquil/default.nix
+++ b/pkgs/development/python-modules/pyquil/default.nix
@@ -14,6 +14,7 @@
   pytest-asyncio,
   pytest-mock,
   pytestCheckHook,
+  pythonAtLeast,
   qcs-sdk-python,
   respx,
   rpcq,
@@ -28,6 +29,9 @@ buildPythonPackage rec {
   version = "4.17.0";
   pyproject = true;
 
+  # qcs-sdk-python (PyO3) caps at 3.12; upstream also pins python <3.13
+  disabled = pythonAtLeast "3.13";
+
   src = fetchFromGitHub {
     owner = "rigetti";
     repo = "pyquil";