diff --git a/pkgs/development/libraries/gtk-frdp/default.nix b/pkgs/development/libraries/gtk-frdp/default.nix
index 4498930bd838..a76805d8d1fb 100644
--- a/pkgs/development/libraries/gtk-frdp/default.nix
+++ b/pkgs/development/libraries/gtk-frdp/default.nix
@@ -44,6 +44,11 @@ stdenv.mkDerivation rec {
     };
   };
 
+  NIX_CFLAGS_COMPILE = lib.optional stdenv.isDarwin [
+    "-DTARGET_OS_IPHONE=0"
+    "-DTARGET_OS_WATCH=0"
+  ];
+
   meta = with lib; {
     homepage = "https://gitlab.gnome.org/GNOME/gtk-frdp";
     description = "RDP viewer widget for GTK";