diff --git a/pkgs/development/python-modules/libusbsio/default.nix b/pkgs/development/python-modules/libusbsio/default.nix
new file mode 100644
index 000000000000..b6cab59570b9
--- /dev/null
+++ b/pkgs/development/python-modules/libusbsio/default.nix
@@ -0,0 +1,34 @@
+{ lib, buildPythonPackage, libusbsio }:
+
+buildPythonPackage rec {
+  pname = "libusbsio";
+  inherit (libusbsio) version;
+
+  src = "${libusbsio.src}/python";
+
+  # The source includes both the python module directly and also a source tarball for it.
+  # The direct files lack setup information, the tarball includes unwanted binaries.
+  # This takes only the setup files from the tarball.
+  postUnpack = ''
+    tar -C python --strip-components=1 -xf python/dist/libusbsio-${version}.tar.gz libusbsio-${version}/{setup.py,setup.cfg,pyproject.toml}
+    rm -r python/dist
+  '';
+
+  postPatch = ''
+    substituteInPlace libusbsio/libusbsio.py \
+        --replace "dllpath = LIBUSBSIO._lookup_dll_path(dfltdir, dllname)" 'dllpath = "${libusbsio}/lib/" + dllname'
+  '';
+
+  buildInputs = [ libusbsio ];
+
+  doCheck = false; # they require a device to be connected over USB
+
+  pythonImportsCheck = [ "libusbsio" ];
+
+  meta = with lib; {
+    description = "NXP Secure Provisioning SDK";
+    homepage = "https://github.com/NXPmicro/spsdk";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ frogamic sbruder ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b6cc1b7db6b1..b89cd79705ff 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5128,6 +5128,10 @@ in {
     inherit (pkgs) libusb1;
   };
 
+  libusbsio = callPackage ../development/python-modules/libusbsio {
+    inherit (pkgs) libusbsio;
+  };
+
   libversion = callPackage ../development/python-modules/libversion {
     inherit (pkgs) libversion;
   };